Biomaterial Database

[Hematopoietic stem cell transplantation: principles and practice]. 1996

S Burdach, and W Nürnberger, and U Göbel

Klinik für Pädiatrische Hämatologie und Onkologie, Heinrich-Heine-Universität Düsseldorf.

This article describes the basic definitions, indications and complications of hematopoietic stem cell transplantation. The different modes of transplantation (autologous, allogeneic-related and allogeneic-unrelated transplantation) are explained with regard to the underlying immunological processes and consequences for duration of treatment, distribution of age, complications, lethality, and for the family of the patient. In our department, the duration of the hospital stay was (median) 44 days for autologous BMT, 45 days for allogeneic-related BMT and 66 days for allogeneic-unrelated BMT. Six to twelve years old children showed a peak for allogeneic related transplantations; these children were treated mainly for relapse of acute lymphoblastic or myeloid leukemias. Patients over 15 years old showed a peak for autologous transplantations; due to the research focus of our center, Ewing's sarcoma was the main underlying disease in this age group. Allogeneic-unrelated transplantations were uniformly distributed over the whole age range from nine months to 24 years.

UI	MeSH Term	Description	Entries
D007108	Immune Tolerance	The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.	Immunosuppression (Physiology),Immunosuppressions (Physiology),Tolerance, Immune
D007166	Immunosuppressive Agents	Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.	Immunosuppressant,Immunosuppressive Agent,Immunosuppressants,Agent, Immunosuppressive,Agents, Immunosuppressive
D007223	Infant	A child between 1 and 23 months of age.	Infants
D001859	Bone Neoplasms	Tumors or cancer located in bone tissue or specific BONES.	Bone Cancer,Cancer of Bone,Cancer of the Bone,Neoplasms, Bone,Bone Neoplasm,Neoplasm, Bone
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D002675	Child, Preschool	A child between the ages of 2 and 5.	Children, Preschool,Preschool Child,Preschool Children
D006087	Graft vs Host Reaction	An immunological attack mounted by a graft against the host because of HISTOINCOMPATIBILITY when immunologically competent cells are transplanted to an immunologically incompetent host; the resulting clinical picture is that of GRAFT VS HOST DISEASE.	HLA Sensitization,Human Leukocyte Antigen Sensitization,Sensitization, HLA
D006412	Hematopoietic Stem Cells	Progenitor cells from which all blood cells derived. They are found primarily in the bone marrow and also in small numbers in the peripheral blood.	Colony-Forming Units, Hematopoietic,Progenitor Cells, Hematopoietic,Stem Cells, Hematopoietic,Hematopoietic Progenitor Cells,Cell, Hematopoietic Progenitor,Cell, Hematopoietic Stem,Cells, Hematopoietic Progenitor,Cells, Hematopoietic Stem,Colony Forming Units, Hematopoietic,Colony-Forming Unit, Hematopoietic,Hematopoietic Colony-Forming Unit,Hematopoietic Colony-Forming Units,Hematopoietic Progenitor Cell,Hematopoietic Stem Cell,Progenitor Cell, Hematopoietic,Stem Cell, Hematopoietic,Unit, Hematopoietic Colony-Forming,Units, Hematopoietic Colony-Forming
D006789	Host vs Graft Reaction	The immune responses of a host to a graft. A specific response is GRAFT REJECTION.
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man