Biomaterial Database

Use of drugs in ointment for routine mydriasis. 1977

R O Hendrickson, and C Hanna

The mydriatic effect produced by ointment preparations of cyclopentolate 1%, tropicamide 1%, and phenylephrine hydrochloride 10% was compared to the mydriasis elicited by the aqueous solutions of the same concentrations of drugs in children and adults. There was no difference in the amount of mydriasis produced by one instillation of a very small volume of the drug in ointment in one eye when compared to multiple instillations of the aqueous solution of the same drug in the contralateral eye in 30 minutes. There were no complaints of ocular irritation when the ointment preparations were instilled into the eye; however, there were frequent complaints with the use of these drugs in aqueous solutions.

UI	MeSH Term	Description	Entries
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D009184	Mydriatics	Agents that dilate the pupil. They may be either sympathomimetics or parasympatholytics.	Cycloplegic,Cycloplegics,Mydriatic,Mydriatic Effect,Mydriatic Effects,Effect, Mydriatic,Effects, Mydriatic
D009824	Ointments	Semisolid preparations used topically for protective emollient effects or as a vehicle for local administration of medications. Ointment bases are various mixtures of fats, waxes, animal and plant oils and solid and liquid hydrocarbons.	Ointment,Paste,Pastes,Salve,Unguent,Salves,Skin Ointment,Unguents,Ointment, Skin
D009883	Ophthalmic Solutions	Sterile solutions that are intended for instillation into the eye. It does not include solutions for cleaning eyeglasses or CONTACT LENS SOLUTIONS.	Eye Drop,Eyedrop,Eyedrops,Ophthalmic Solution,Eye Drops,Drop, Eye,Drops, Eye,Solution, Ophthalmic,Solutions, Ophthalmic
D010656	Phenylephrine	An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.	(R)-3-Hydroxy-alpha-((methylamino)methyl)benzenemethanol,Metaoxedrin,Metasympatol,Mezaton,Neo-Synephrine,Neosynephrine,Phenylephrine Hydrochloride,Phenylephrine Tannate,Neo Synephrine,Tannate, Phenylephrine
D011680	Pupil	The aperture in the iris through which light passes.	Pupils
D011725	Pyridines	Compounds with a six membered aromatic ring containing NITROGEN. The saturated version is PIPERIDINES.
D012029	Refraction, Ocular	Refraction of LIGHT effected by the media of the EYE.	Ocular Refraction,Ocular Refractions,Refractions, Ocular
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D002675	Child, Preschool	A child between the ages of 2 and 5.	Children, Preschool,Preschool Child,Preschool Children