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The influence of 100--600 microng of gamma-aminobutyric acid (GABA) injected into the right lateral ventricle of the brain on behavior and activity of the cerebral cholinergic system was studied in Wistar rats. Proportionally to dosage, GABA inhibited motor and exploratory activity in the rats. Reduction in the content of acetylcholine in the pons and medulla oblongata was accompanied by increased acetylcholinesterase (AChE) activity. GABA changed AChE activity differently in various parts of the brain. GABA depressed motor and exploratory activity in rats in a degree dependent on its dosage and inborn exploratory of the rats, and this effect was accompanied by changes in the cerebral cholinergic system.
K Kmieciak-Kolada, and
Z S Herman, and
J Kozok, and
E Bień, and
A Szwed
February 1958,
Science (New York, N.Y.),
K Kmieciak-Kolada, and
Z S Herman, and
J Kozok, and
E Bień, and
A Szwed
January 1963,
Nervnaia sistema,
K Kmieciak-Kolada, and
Z S Herman, and
J Kozok, and
E Bień, and
A Szwed
January 1983,
Farmakologiia i toksikologiia,
K Kmieciak-Kolada, and
Z S Herman, and
J Kozok, and
E Bień, and
A Szwed
January 1960,
Revue des sciences medicales,
K Kmieciak-Kolada, and
Z S Herman, and
J Kozok, and
E Bień, and
A Szwed
February 1990,
Japanese journal of pharmacology,
K Kmieciak-Kolada, and
Z S Herman, and
J Kozok, and
E Bień, and
A Szwed
July 1964,
Life sciences (1962),
K Kmieciak-Kolada, and
Z S Herman, and
J Kozok, and
E Bień, and
A Szwed
January 1963,
Therapie,
K Kmieciak-Kolada, and
Z S Herman, and
J Kozok, and
E Bień, and
A Szwed
October 1964,
British journal of pharmacology and chemotherapy,
K Kmieciak-Kolada, and
Z S Herman, and
J Kozok, and
E Bień, and
A Szwed
January 1964,
Farmakologiia i toksikologiia,
K Kmieciak-Kolada, and
Z S Herman, and
J Kozok, and
E Bień, and
A Szwed
September 1985,
Neuroscience letters,
