Biomaterial Database

A search for antitumor compounds. XII. Biologic studies. Antitumor properties of 12 new 1-nitro-9alkylaminoalkylaminoacridines. 1977

M Hrabowska, and A Ledóchowski, and K Onoszko

Results of the studies on antitumor activity of 12 new 1-nitro-9-alkylaminoalkylaminacridines in mice bearing Sa-180 are presented. Only one of these compounds, viz. C-846 was active repeatedly in Sa-180 test; the activity of 5 other compounds tested (C-845, C-848, C-852, C-865 and C-866) requires further elucidation by means of new tests with Sa-180. The remaining 6 compounds were inactive. Some other general effects in mice bearing Sa-180 and some aspects of the structure-activity relationship are discussed.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009368	Neoplasm Transplantation	Experimental transplantation of neoplasms in laboratory animals for research purposes.	Transplantation, Neoplasm,Neoplasm Transplantations,Transplantations, Neoplasm
D009564	Nitracrine	Acridine antineoplastic agent used in mammary and ovarian tumors. It inhibits RNA synthesis.	C-283,Ledakrin,C 283,C283
D004353	Drug Evaluation, Preclinical	Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.	Drug Screening,Evaluation Studies, Drug, Pre-Clinical,Drug Evaluation Studies, Preclinical,Drug Evaluations, Preclinical,Evaluation Studies, Drug, Preclinical,Evaluation, Preclinical Drug,Evaluations, Preclinical Drug,Medicinal Plants Testing, Preclinical,Preclinical Drug Evaluation,Preclinical Drug Evaluations,Drug Screenings,Screening, Drug,Screenings, Drug
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000166	Acridines	Compounds that include the structure of acridine.	Acridine
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012510	Sarcoma 180	An experimental sarcoma of mice.	Sarcoma 180, Crocker,Crocker Sarcoma 180
D013329	Structure-Activity Relationship	The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.	Relationship, Structure-Activity,Relationships, Structure-Activity,Structure Activity Relationship,Structure-Activity Relationships