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Duplicate trials with mibolerone at a dose of 1 microng/g of diet for the first 49 days of age reduced the incidence of lymphoid leukosis (LL) significantly (P less than .005) in chickens inoculated as day-old chicks with Rous-associated virus type 1 (RAV-1). The incidence of LL was not reduced in virus-challenged chickens administered mibolerone at 4 microng per gram of diet during days 29 through 49 of age. The bursal lymphocytic follicles atrophied significantly with both the 1- and 4-microng doses; but, on the basis of histologic examination, atrophy was more complete with the 1-microng dose of mibolerone administered during the first 49 days of age. Mibolerone appears to prevent LL development by producing early bursal atrophy of key target cells. These data suggest that mibolerone orally administered at 1 microng/g of diet during the first 49 days of age appears to be useful for LL prophylaxis. Field trials are under way to assess the effectiveness of mibolerone under natural conditions.
T J Kakuk, and
F R Frank, and
T E Weddon
January 1978,
Avian pathology : journal of the W.V.P.A,
T J Kakuk, and
F R Frank, and
T E Weddon
January 1986,
Current topics in microbiology and immunology,
T J Kakuk, and
F R Frank, and
T E Weddon
March 1981,
Journal of the National Cancer Institute,
T J Kakuk, and
F R Frank, and
T E Weddon
February 1976,
Cancer research,
T J Kakuk, and
F R Frank, and
T E Weddon
January 1988,
Advances in veterinary science and comparative medicine,
T J Kakuk, and
F R Frank, and
T E Weddon
January 1972,
National Institute of Animal Health quarterly,
T J Kakuk, and
F R Frank, and
T E Weddon
January 1998,
The Journal of veterinary medical science,
T J Kakuk, and
F R Frank, and
T E Weddon
August 1968,
Journal of the National Cancer Institute,
T J Kakuk, and
F R Frank, and
T E Weddon
January 1974,
National Institute of Animal Health quarterly,
T J Kakuk, and
F R Frank, and
T E Weddon
May 1975,
The Veterinary record,
