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A number of recent studies have implicated the angiotensinogen gene in the aetiology of essential hypertension in Caucasian, Japanese and African Caribbean subjects. We have genotyped 153 healthy white Caucasian subjects at a dinucleotide repeat polymorphism and seven diallelic sites in the coding or flanking regions of the angiotensinogen gene, including one polymorphism not previously studied. We have also documented patterns of linkage disequilibrium between polymorphisms. There is evidence of variation in the frequency of several mutations when compared with published results from other Caucasian control populations, possibly due to cryptic ethnic differences between these groups. This should be considered in the design and interpretation of studies of the angiotensinogen gene.
L Morgan, and
F Broughton Pipkin, and
N Kalsheker
July 1990,
Human genetics,
L Morgan, and
F Broughton Pipkin, and
N Kalsheker
January 1995,
European journal of human genetics : EJHG,
L Morgan, and
F Broughton Pipkin, and
N Kalsheker
September 2001,
Journal of immunology (Baltimore, Md. : 1950),
L Morgan, and
F Broughton Pipkin, and
N Kalsheker
April 2006,
Drug metabolism and pharmacokinetics,
L Morgan, and
F Broughton Pipkin, and
N Kalsheker
October 2002,
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae,
L Morgan, and
F Broughton Pipkin, and
N Kalsheker
January 2009,
Annals of human biology,
L Morgan, and
F Broughton Pipkin, and
N Kalsheker
February 2009,
BMC bioinformatics,
L Morgan, and
F Broughton Pipkin, and
N Kalsheker
September 2007,
Genetics,
L Morgan, and
F Broughton Pipkin, and
N Kalsheker
August 1994,
Human genetics,
L Morgan, and
F Broughton Pipkin, and
N Kalsheker
January 1993,
Human genetics,
