Biomaterial Database

Modification of fatty acid composition of rat heart lipids by feeding cod liver oil. 1977

S Gudbjarnason, and G Oskarsdottir

Modification of the fatty acid composition of cardiac phospholipids and neutral lipids was studied in rats fed a diet containing 10% cod liver oil. The results reflect the dynamic state of esterified fatty acids in neutral lipids and phospholipids of heart muscle. In cardiac neutral lipids there was a moderate but significant increase in exogenous fatty acids, 20:1(n--9), 22:1(n--11), 20:5(n--3) and 22:6(n--3), in animals fed cod liver oil, and a relative decrease in endogenous fatty acids, 16:0, 18:2(n--6 and 20:4(n--6). Increased dietary availability of 22: 6(n--3) resulted in a major increase in the content of this fatty acid in phospholipids and replacement of 18:2(n--6) and 20:4(n--6). The 22:6(n--3) was able to replace one third of 18:2(n--6): further increase in 22: 6n--3) was accompanied by a decrease in 18:0. An inverse relationship between (n--6) and (n--3) polyene fatty acids in cardiac phospholipids suggests a replacement of (n--6) acids by (n--3) fatty acids.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009206	Myocardium	The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.	Muscle, Cardiac,Muscle, Heart,Cardiac Muscle,Myocardia,Cardiac Muscles,Heart Muscle,Heart Muscles,Muscles, Cardiac,Muscles, Heart
D010743	Phospholipids	Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.	Phosphatides,Phospholipid
D003060	Cod Liver Oil	Oil obtained from fresh livers of the cod family, Gadidae. It is a source of VITAMIN A and VITAMIN D.	Liver Oil, Cod,Oil, Cod Liver
D004041	Dietary Fats	Fats present in food, especially in animal products such as meat, meat products, butter, ghee. They are present in lower amounts in nuts, seeds, and avocados.	Fats, Dietary,Dietary Fat,Fat, Dietary
D005227	Fatty Acids	Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)	Aliphatic Acid,Esterified Fatty Acid,Fatty Acid,Fatty Acids, Esterified,Fatty Acids, Saturated,Saturated Fatty Acid,Aliphatic Acids,Acid, Aliphatic,Acid, Esterified Fatty,Acid, Saturated Fatty,Esterified Fatty Acids,Fatty Acid, Esterified,Fatty Acid, Saturated,Saturated Fatty Acids
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus