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We have been interested in the effects of some popular peptides on tracheal smooth muscle. Previously, we reported that atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP) had dose-dependent relaxant effects on guinea pig tracheal smooth muscle. In this study, we compared the effects of ANP, BNP and CNP on histamine release from rat peritoneal mast cells. ANP and BNP were more potent than CNP, dose-dependently increasing histamine release at a concentration of 10(-7) M or higher. CNP induced histamine release at a concentration of 10(-6) M or higher. Extracellular calcium inhibited the histamine release induced by all 3 peptides. In conclusion, the effects of these 3 peptides in rat peritoneal mast cells demonstrated adverse reactions for respiratory diseases, although our previous results showed that these peptides caused relaxation of guinea pig tracheal smooth muscle. We should note that the drugs have different actions in each organ.
H Yoshida, and
Y Inagaki, and
K Yamaki, and
Y Beppu, and
T Kawashima, and
K Takagi
September 2001,
Peptides,
H Yoshida, and
Y Inagaki, and
K Yamaki, and
Y Beppu, and
T Kawashima, and
K Takagi
December 1981,
European journal of pharmacology,
H Yoshida, and
Y Inagaki, and
K Yamaki, and
Y Beppu, and
T Kawashima, and
K Takagi
May 1994,
Biological & pharmaceutical bulletin,
H Yoshida, and
Y Inagaki, and
K Yamaki, and
Y Beppu, and
T Kawashima, and
K Takagi
April 1988,
European journal of pharmacology,
H Yoshida, and
Y Inagaki, and
K Yamaki, and
Y Beppu, and
T Kawashima, and
K Takagi
September 1993,
Agents and actions,
H Yoshida, and
Y Inagaki, and
K Yamaki, and
Y Beppu, and
T Kawashima, and
K Takagi
February 1996,
Biological & pharmaceutical bulletin,
H Yoshida, and
Y Inagaki, and
K Yamaki, and
Y Beppu, and
T Kawashima, and
K Takagi
December 1967,
Acta physiologica Scandinavica,
H Yoshida, and
Y Inagaki, and
K Yamaki, and
Y Beppu, and
T Kawashima, and
K Takagi
July 1985,
European journal of pharmacology,
H Yoshida, and
Y Inagaki, and
K Yamaki, and
Y Beppu, and
T Kawashima, and
K Takagi
September 1982,
Klinische Wochenschrift,
H Yoshida, and
Y Inagaki, and
K Yamaki, and
Y Beppu, and
T Kawashima, and
K Takagi
October 1985,
European journal of pharmacology,
