-transparent.png){kind=logo}
Tissue factor (TF) plays a key role as a primary initiator on the extrinsic coagulation cascade. Recently, upregulation of TF has been reported in human atherosclerotic lesions. We investigated the effects of TF on migration and proliferation of cultured smooth muscle cells (SMCs) from rabbit aortas. We tested three kinds of recombinant human TF (L-TF: the full length of TF with relipidation, NL-TF: the full length of TF without relipidation, and S-TF: a soluble form of TF1-219). Only L-TF had coagulant activity. All kinds of TF showed the chemotactic migration activity for SMCs. The migration ability of TFs was comparable to those of platelet-derived growth factor (PDGF)-BB and basic fibroblast-growth factor (bFGF), and was inhibited by anti-TF polyclonal and monoclonal antibodies. On the other hand, none of the forms of TF induced SMC proliferation. These results indicate that TF is not only a coagulation factor but also a strong chemotactic factor for vascular SMCs, and suggest that TF could play an important role in atherogenesis as well as in hemostasis and thrombosis.
Y Sato, and
Y Asada, and
K Marutsuka, and
K Hatakeyama, and
A Sumiyoshi
January 2021,
The Journal of toxicological sciences,
Y Sato, and
Y Asada, and
K Marutsuka, and
K Hatakeyama, and
A Sumiyoshi
March 2000,
European journal of pharmacology,
Y Sato, and
Y Asada, and
K Marutsuka, and
K Hatakeyama, and
A Sumiyoshi
February 2006,
Journal of thrombosis and haemostasis : JTH,
Y Sato, and
Y Asada, and
K Marutsuka, and
K Hatakeyama, and
A Sumiyoshi
November 2000,
Journal of cardiovascular pharmacology,
Y Sato, and
Y Asada, and
K Marutsuka, and
K Hatakeyama, and
A Sumiyoshi
June 1990,
Biochemical and biophysical research communications,
Y Sato, and
Y Asada, and
K Marutsuka, and
K Hatakeyama, and
A Sumiyoshi
November 1999,
Circulation,
Y Sato, and
Y Asada, and
K Marutsuka, and
K Hatakeyama, and
A Sumiyoshi
January 1991,
Blood vessels,
Y Sato, and
Y Asada, and
K Marutsuka, and
K Hatakeyama, and
A Sumiyoshi
January 1989,
Artery,
Y Sato, and
Y Asada, and
K Marutsuka, and
K Hatakeyama, and
A Sumiyoshi
April 1988,
Circulation research,
Y Sato, and
Y Asada, and
K Marutsuka, and
K Hatakeyama, and
A Sumiyoshi
October 1999,
Thrombosis and haemostasis,
