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[The vaccinal prophylaxis of hepatitis B among children born to mothers with persistent HBs-antigenemia]. 1996
P A Khukhlovich, and
I V Shakhgil'dian, and
M I Narkevich, and
V A Anan'ev, and
S N Kuzin, and
N A Sergeeva, and
Sh Kh Khodzhaev, and
P I Iarovoĭ, and
Zh A Drobeniuk, and
A K Iuldashev, and
M A Khodzhaeva, and
O N Makmudova, and
A Ia Buriev, and
R A Rakhimov, and
G M Tuliaganova, and
V A Khasanova, and
M I Tsvaĭner, and
T S Eliseeva, and
M A Tuĭchibaeva, and
L V Mineecheva, and
E I Kotsaga, and
V I Nagachevskaia, and
N Kh Rafikova, and
S M Klimenko
In Uzbekistan and Moldova 542 children born of HBsAg carriers were immunized against hepatitis B (with vaccine Engerix B according to the immunization schedule of 4 injections). Anti-HBs antibodies in protective titers were detected by EIA and RIA techniques in 76.7% of children aged 4-5 months after the 3rd injection, in 95.7% of children aged 15-16 months and in 90.0% of children aged 2-2.5 years after the 4th (booster) injection. In the control group (117 nonimmunized children born of HBs carriers) observed during the same period anti-HBs antibodies were detected significantly less frequently (in 7.3%, 11.6% and 12.9% of these children respectively). 1-2 months after the course of immunization was completed 74.1% of the immunized children had high anti-HBs antibody titers (exceeding 1000 IU/ml) with their subsequent decrease by 2-2.5 years of age. In the control group these figures were 27.1% and 29.0% respectively. The index of immunization effectiveness obtained by the comparison of the hepatitis B morbidity rates in both groups was 7.8. No postvaccinal complications were registered.
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N Kh Rafikova, and
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