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OBJECTIVE To investigate the pharmacokinetics of ceftizoxime (Cef) in renal failure patients without any dialysis and supply the basis for a suitable clinical regimen. METHODS Cef in plasma and urine was assayed by HPLC. RESULTS After injecting Cef 16.7 mg kg-1, Cef concentration in blood was described as a 2-compartment open model. The main pharmacokinetic parameters were Vd 0.55 +/- 0.17 L kg-1; AUC 879 +/- 460 mg L-1 h; Cl 27 +/- 11 mL kg-1 h-1. T1/2 beta was 15 +/- 4 h. CONCLUSIONS T1/2 beta in renal failure patients was about 10 times longer than that in normal volunteers. The clinical regimen should be adjusted in renal failure patients with infection, either prolonging the interval between Cef administration, or decreasing Cef dosage.
P Li, and
Q Cai, and
S Gao, and
G L Liu, and
R L Cui, and
X Y Yang
August 1983,
Antimicrobial agents and chemotherapy,
P Li, and
Q Cai, and
S Gao, and
G L Liu, and
R L Cui, and
X Y Yang
March 1985,
Clinical nephrology,
P Li, and
Q Cai, and
S Gao, and
G L Liu, and
R L Cui, and
X Y Yang
January 1982,
Arzneimittel-Forschung,
P Li, and
Q Cai, and
S Gao, and
G L Liu, and
R L Cui, and
X Y Yang
November 1991,
Clinical pharmacokinetics,
P Li, and
Q Cai, and
S Gao, and
G L Liu, and
R L Cui, and
X Y Yang
October 1986,
The Japanese journal of antibiotics,
P Li, and
Q Cai, and
S Gao, and
G L Liu, and
R L Cui, and
X Y Yang
September 1995,
European journal of anaesthesiology. Supplement,
P Li, and
Q Cai, and
S Gao, and
G L Liu, and
R L Cui, and
X Y Yang
January 2006,
EDTNA/ERCA journal (English ed.),
P Li, and
Q Cai, and
S Gao, and
G L Liu, and
R L Cui, and
X Y Yang
January 1982,
Methods and findings in experimental and clinical pharmacology,
P Li, and
Q Cai, and
S Gao, and
G L Liu, and
R L Cui, and
X Y Yang
July 1986,
The Journal of antimicrobial chemotherapy,
P Li, and
Q Cai, and
S Gao, and
G L Liu, and
R L Cui, and
X Y Yang
October 1971,
La Presse medicale,
