Toxocariasis: a cause of hyper IgE and eosinophilia. 1995

J Arias Irigoyen, and C J Senent Sánchez
Allergy Section, Virgen del Valle Hospital, Toledo, Spain.

We present a patient with elevation of total serum IgE, eosinophilia and Toxocara exoantigen specific IgG and IgE antibodies (detected by ELISA and RAST, respectively). We ruled out atopy and other parasitic diseases common in our habitat (e.g., Echinococcus granulosus, Ascaris lumbricoides, Schistosoma mansoni). The patient was asymptomatic over the four years of the study, and the levels of total serum IgE, eosinophils and Toxocara exoantigen specific IgG and IgE remained high. Although at present, immunodiagnostic tests have a high sensitivity and specificity for toxocariasis, their value is limited. This is illustrated by the fact that in our patient these techniques could not distinguish between past and present infection.

UI MeSH Term Description Entries
D007073 Immunoglobulin E An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE). IgE
D004802 Eosinophilia Abnormal increase of EOSINOPHILS in the blood, tissues or organs. Eosinophilia, Tropical,Hypereosinophilia,Tropical Eosinophilia,Hypereosinophilias,Tropical Eosinophilias
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000909 Antibodies, Helminth Immunoglobulins produced in a response to HELMINTH ANTIGENS. Helminth Antibodies
D014120 Toxocariasis Infection by round worms of the genus TOXOCARA, usually found in wild and domesticated cats and dogs and foxes, except for the larvae, which may produce visceral and ocular larva migrans in man. Toxocariases

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