-transparent.png){kind=logo}
Low-affinity nerve growth factor (NGF) receptors are present on the cholinergic neurons of the basal forebrain. We studied the effects of 192 IgG-saporin, a specific immunotoxin for the NGF receptor-positive, cholinergic basal forebrain neurons, on sleep, the power spectrum of the electroencephalogram (EEG), and body temperature. After 3 d baseline recordings, 12 male rats were injected intracerebroventricularly with 4 micrograms 192 IgG-saporin. EEG, motor activity, and brain temperature were recorded for 23 h on the first, third, fifth, and seventh day after the treatment. 192 IgG-saporin did not affect the total daily amounts but altered the circadian distribution of sleep. On days 1 and 3 after the injection of the immunotoxin, the amount of non-rapid-eye-movement sleep (NREMS) and rapid-eye-movement sleep (REMS) increased during the dark period, whereas during the light both NREMS and REMS decreased. On day 5, these changes were less pronounced and sleep completely returned to the baseline by day 7. The EEG was suppressed in each frequency band and each vigilance state, and, in contrast to sleep, these changes in EEG persisted for 7 days. Brain temperature was decreased from day 3. These results suggest that NGF receptor-positive, cholinergic basal forebrain neurons are not necessary for the maintenance of total sleep time but contribute to the generation of normal EEG and the maintenance of brain temperature.
L Kapás, and
F Obál, and
A A Book, and
J B Schweitzer, and
R G Wiley, and
J M Krueger
July 1995,
Neuroscience letters,
L Kapás, and
F Obál, and
A A Book, and
J B Schweitzer, and
R G Wiley, and
J M Krueger
January 2001,
Brain research bulletin,
L Kapás, and
F Obál, and
A A Book, and
J B Schweitzer, and
R G Wiley, and
J M Krueger
September 2003,
Neuroscience and biobehavioral reviews,
L Kapás, and
F Obál, and
A A Book, and
J B Schweitzer, and
R G Wiley, and
J M Krueger
January 2016,
Current topics in behavioral neurosciences,
L Kapás, and
F Obál, and
A A Book, and
J B Schweitzer, and
R G Wiley, and
J M Krueger
October 2006,
The European journal of neuroscience,
L Kapás, and
F Obál, and
A A Book, and
J B Schweitzer, and
R G Wiley, and
J M Krueger
October 1996,
Brain research. Developmental brain research,
L Kapás, and
F Obál, and
A A Book, and
J B Schweitzer, and
R G Wiley, and
J M Krueger
June 2002,
Brain research bulletin,
L Kapás, and
F Obál, and
A A Book, and
J B Schweitzer, and
R G Wiley, and
J M Krueger
November 2008,
Neuroscience,
L Kapás, and
F Obál, and
A A Book, and
J B Schweitzer, and
R G Wiley, and
J M Krueger
January 1995,
Acta neuropathologica,
L Kapás, and
F Obál, and
A A Book, and
J B Schweitzer, and
R G Wiley, and
J M Krueger
September 1994,
Neuroreport,
