This study investigated perceived locus of control as a function of level of depression among 39 alcoholics and 39 matched nonalcoholic controls. Ss completed the Rotter I-E scale and the Beck Depression Inventory. Initial analyses of variance indicated a lack of difference between groups on the I-E scale; however, alcoholics were significantly more depressed than were controls. A correlational analysis indicated a significant relationship between an external locus of control and higher levels of depression. When level of depression was controlled statistically, an alalysis of covariance indicated that the alcoholic samples was significantly more internal than the nonalcoholics. These data tend to cross-validate Lamont's (1972) findings of an item-mood response bias in the I-E scale. These data further support the contention that caution must be used in interpreting comparative locus of control results derived from samples that have differential base rates of depression.