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BACKGROUND Plasma concentrations of atrial natriuretic peptide (ANP) are increased in patients with ventricular dysfunction and could have a diagnostic role in heart failure. ANP may be unstable after collection, however, limiting any practical diagnostic role. METHODS Blood samples were obtained from 18 patients with various conditions. Aliquots were either processed optimally or kept as blood or plasma at room temperature for 6-72 h before processing. RESULTS Concentrations of C-terminal ANP were lower in specimens kept as blood for 24 and 72 h (mean difference from control -43% and -76%, respectively, (P < 0.001) but N-terminal ANP (extracted) seemed to be stable under all conditions studied (-2% at 24 h and -7% at 72 h, not significant). CONCLUSIONS N-terminal ANP (extracted) is stable and potentially has a role in the diagnosis of heart failure in routine clinical practice.
J G Cleland, and
S Ward, and
D Dutka, and
F Habib, and
M Impallomeni, and
I J Morton
April 1997,
Heart (British Cardiac Society),
J G Cleland, and
S Ward, and
D Dutka, and
F Habib, and
M Impallomeni, and
I J Morton
January 2000,
Postepy higieny i medycyny doswiadczalnej,
J G Cleland, and
S Ward, and
D Dutka, and
F Habib, and
M Impallomeni, and
I J Morton
June 1988,
Bioorganicheskaia khimiia,
J G Cleland, and
S Ward, and
D Dutka, and
F Habib, and
M Impallomeni, and
I J Morton
June 1988,
Bioorganicheskaia khimiia,
J G Cleland, and
S Ward, and
D Dutka, and
F Habib, and
M Impallomeni, and
I J Morton
May 2001,
Regulatory peptides,
J G Cleland, and
S Ward, and
D Dutka, and
F Habib, and
M Impallomeni, and
I J Morton
January 1987,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
J G Cleland, and
S Ward, and
D Dutka, and
F Habib, and
M Impallomeni, and
I J Morton
October 2020,
Journal of the American Heart Association,
J G Cleland, and
S Ward, and
D Dutka, and
F Habib, and
M Impallomeni, and
I J Morton
June 1992,
Transplantation,
J G Cleland, and
S Ward, and
D Dutka, and
F Habib, and
M Impallomeni, and
I J Morton
September 2012,
Journal of pediatric intensive care,
J G Cleland, and
S Ward, and
D Dutka, and
F Habib, and
M Impallomeni, and
I J Morton
December 1990,
American journal of hypertension,
