BIOMAT Database Logo BIOMAT Database Logo

Increased pulmonary vascular resistance with systemic hypertension. Effect of minoxidil and other antihypertensive agents. 1977

J M Atkins, and H C Mitchell, and W A Pettinger

Recent case reports suggest that pulmonary hypertension could be caused by minoxidil, a new potent vasodilating antihypertensive drug. Therefore, we evaluated the incidence and severity of pulmonary hypertension in 110 patients with systemic hypertension. Fourteen patients were treated with minoxidil for 2 to 35 months (mean 19.9 months), 15 were treated with no drugs, and the remaining 81 patients received conventional antihypertensive agents of several types. Pulmonary vascular resistance correlated positively (P is less than 0.05) with systemic vascular resistance. Minoxidil-treated patients with hypertension previously refractory to conventional therapy had slightly lower pulmonary vascular resistance than other hypertensive subjects. There was no correlation between pulmonary vascular resistance and duration of minoxidil therapy or other types of antihypertensive regimens. The positive correlation between pulmonary and systemic vascular resistance suggests the possibility of a causal hypertension relation in the two vascular beds.

UI MeSH Term Description Entries
D006973 Hypertension Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. Blood Pressure, High,Blood Pressures, High,High Blood Pressure,High Blood Pressures
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D008914 Minoxidil A potent direct-acting peripheral vasodilator (VASODILATOR AGENTS) that reduces peripheral resistance and produces a fall in BLOOD PRESSURE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p371) Loniten,Regaine,Rogaine,U 10858
D011651 Pulmonary Artery The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs. Arteries, Pulmonary,Artery, Pulmonary,Pulmonary Arteries
D011652 Pulmonary Circulation The circulation of the BLOOD through the LUNGS. Pulmonary Blood Flow,Respiratory Circulation,Circulation, Pulmonary,Circulation, Respiratory,Blood Flow, Pulmonary,Flow, Pulmonary Blood,Pulmonary Blood Flows
D011743 Pyrimidines A family of 6-membered heterocyclic compounds occurring in nature in a wide variety of forms. They include several nucleic acid constituents (CYTOSINE; THYMINE; and URACIL) and form the basic structure of the barbiturates.
D001794 Blood Pressure PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS. Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D005260 Female Females
D006328 Cardiac Catheterization Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures. Catheterization, Cardiac,Catheterization, Heart,Heart Catheterization,Cardiac Catheterizations,Catheterizations, Cardiac,Catheterizations, Heart,Heart Catheterizations

Related Publications

J M Atkins, and H C Mitchell, and W A Pettinger
Increased systemic vascular resistance in neonates with pulmonary hypertension.
November 1979, The American journal of cardiology,
J M Atkins, and H C Mitchell, and W A Pettinger
Systemic hypertension and antihypertensive agents.
January 1999, Journal of nephrology,
J M Atkins, and H C Mitchell, and W A Pettinger
Pulmonary hemodynamics in systemic hypertension. Long-term effect of minoxidil.
October 1979, Chest,
J M Atkins, and H C Mitchell, and W A Pettinger
Pulmonary arterial hypertension with markedly increased pulmonary resistance; the pulmonary vascular obstruction syndrome.
October 1954, The American journal of medicine,
J M Atkins, and H C Mitchell, and W A Pettinger
Heart transplantation in patients with severe pulmonary hypertension and increased pulmonary vascular resistance.
January 1990, Scandinavian journal of thoracic and cardiovascular surgery,
J M Atkins, and H C Mitchell, and W A Pettinger
The nature of the increased pulmonary vascular resistance in pulmonary hypertension.
July 1958, The Medical clinics of North America,
J M Atkins, and H C Mitchell, and W A Pettinger
Minoxidil reduces pulmonary vascular resistance in dogs and cattle.
December 1976, The Journal of laboratory and clinical medicine,
J M Atkins, and H C Mitchell, and W A Pettinger
The effect of ACE inhibitors and other antihypertensive agents on insulin resistance.
January 1995, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
J M Atkins, and H C Mitchell, and W A Pettinger
Pulmonary hypertension in hypertensive patients: association with diastolic dysfunction and increased pulmonary vascular resistance.
April 2014, Echocardiography (Mount Kisco, N.Y.),
J M Atkins, and H C Mitchell, and W A Pettinger
Increased pulmonary vascular resistance in early stage systemic hypertension: a resting and exercise stress echocardiography study.
April 2015, The Canadian journal of cardiology,
Copied contents to your clipboard!