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Suprarenal aortic constriction sufficient to reduce renal perfusion pressure by approximately 50% increased aldosterone secretion in anesthetized rats pretreated with dexamethasone. Bilateral nephrectomy under the same experimental conditions blocked the aldosterone response. Additionally, [1-sarcosine, 8-alanine]angiotensin II blocked the response in aldosterone secretion to aortic constriction in dexamethasone-treated rats. Finally, in rats hypophysectomized to exclude the influence of ACTH, the aldosterone response to aortic constriction was blocked by [1-sarcosine, 8-alanine]angiotensin II. The results indicate that angiotensin II increased aldosterone secretion during aortic constriction in the rat. These observations, along with those reported previously in sodium-depleted rats, point to an important overall role for the renin-angiotensin system in the control of aldosterone secretion in the rat.
R H Freeman, and
J O Davis, and
W S Spielman
October 1974,
Circulation research,
R H Freeman, and
J O Davis, and
W S Spielman
March 1977,
Circulation research,
R H Freeman, and
J O Davis, and
W S Spielman
June 1977,
The American journal of physiology,
R H Freeman, and
J O Davis, and
W S Spielman
February 1966,
Geburtshilfe und Frauenheilkunde,
R H Freeman, and
J O Davis, and
W S Spielman
January 1974,
Acta physiologica latino americana,
R H Freeman, and
J O Davis, and
W S Spielman
September 1985,
Journal of applied physiology (Bethesda, Md. : 1985),
R H Freeman, and
J O Davis, and
W S Spielman
April 1965,
Endocrinology,
R H Freeman, and
J O Davis, and
W S Spielman
April 1993,
Hypertension (Dallas, Tex. : 1979),
R H Freeman, and
J O Davis, and
W S Spielman
December 1979,
Revista de medicina de la Universidad de Navarra,
R H Freeman, and
J O Davis, and
W S Spielman
August 1978,
Proceedings of the National Academy of Sciences of the United States of America,
