Biomaterial Database

Low-grade dermal angiosarcoma of the breast following radiotherapy. 1996

D J Bolin, and G M Lukas

Kalamazoo Center for Medical Studies, Michigan State University, Michigan, USA.

Dermal angiosarcoma is a rare complication of radiotherapy. It is characterized by an aggressive nature and is distinct from other forms of angiosarcoma in that it does not always present with chronic lymphedema. A few case reports have appeared of cutaneous angiosarcoma arising in women previously treated with breast-conserving treatment and radiation for breast cancer. A review of the literature reveals that these lesions are difficult to diagnose because of their rarity and their highly variable and benign appearance, which may mimic radiation-induced changes in the skin. The majority of the literature reports describe high-grade lesions; only one case of low-grade angiosarcoma was described. We now report a second case of low-grade angiosarcoma arising 10 years after segmental mastectomy, axillary lymph node dissection, and radiation treatment for infiltrating ductal carcinoma. The prompt diagnosis of dermal angiosarcoma is strongly dependent upon a high index of suspicion. Biopsy should be considered in patients who present with new skin lesions after radiation treatment for breast cancer.

UI	MeSH Term	Description	Entries
D009381	Neoplasms, Radiation-Induced	Tumors, cancer or other neoplasms produced by exposure to ionizing or non-ionizing radiation.	Radiation-Induced Cancer,Cancer, Radiation-Induced,Radiation-Induced Neoplasms,Cancer, Radiation Induced,Cancers, Radiation-Induced,Neoplasm, Radiation-Induced,Neoplasms, Radiation Induced,Radiation Induced Cancer,Radiation Induced Neoplasms,Radiation-Induced Cancers,Radiation-Induced Neoplasm
D001943	Breast Neoplasms	Tumors or cancer of the human BREAST.	Breast Cancer,Breast Tumors,Cancer of Breast,Breast Carcinoma,Cancer of the Breast,Human Mammary Carcinoma,Malignant Neoplasm of Breast,Malignant Tumor of Breast,Mammary Cancer,Mammary Carcinoma, Human,Mammary Neoplasm, Human,Mammary Neoplasms, Human,Neoplasms, Breast,Tumors, Breast,Breast Carcinomas,Breast Malignant Neoplasm,Breast Malignant Neoplasms,Breast Malignant Tumor,Breast Malignant Tumors,Breast Neoplasm,Breast Tumor,Cancer, Breast,Cancer, Mammary,Cancers, Mammary,Carcinoma, Breast,Carcinoma, Human Mammary,Carcinomas, Breast,Carcinomas, Human Mammary,Human Mammary Carcinomas,Human Mammary Neoplasm,Human Mammary Neoplasms,Mammary Cancers,Mammary Carcinomas, Human,Neoplasm, Breast,Neoplasm, Human Mammary,Neoplasms, Human Mammary,Tumor, Breast
D005260	Female		Females
D006394	Hemangiosarcoma	A rare malignant neoplasm characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and lining irregular blood-filled or lumpy spaces. (Stedman, 25th ed)	Angiosarcoma,Angiosarcomas,Hemangiosarcomas
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368	Aged	A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available.	Elderly
D012878	Skin Neoplasms	Tumors or cancer of the SKIN.	Cancer of Skin,Skin Cancer,Cancer of the Skin,Neoplasms, Skin,Cancer, Skin,Cancers, Skin,Neoplasm, Skin,Skin Cancers,Skin Neoplasm
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor
D015412	Mastectomy, Segmental	Removal of only enough breast tissue to ensure that the margins of the resected surgical specimen are free of tumor.	Breast-Conserving Surgery,Lumpectomy,Partial Mastectomy,Breast Conservation Therapy,Breast Quadrantectomy,Breast-Sparing Surgery,Limited Resection Mastectomy,Local Excision Mastectomy,Segmentectomy,Surgery, Breast-Conserving,Breast Conservation Therapies,Breast Conserving Surgery,Breast Quadrantectomies,Breast Sparing Surgery,Breast-Conserving Surgeries,Breast-Sparing Surgeries,Conservation Therapies, Breast,Conservation Therapy, Breast,Limited Resection Mastectomies,Local Excision Mastectomies,Lumpectomies,Mastectomies, Limited Resection,Mastectomies, Local Excision,Mastectomies, Partial,Mastectomies, Segmental,Mastectomy, Limited Resection,Mastectomy, Local Excision,Mastectomy, Partial,Partial Mastectomies,Quadrantectomies, Breast,Quadrantectomy, Breast,Segmental Mastectomies,Segmental Mastectomy,Segmentectomies,Surgeries, Breast-Conserving,Surgeries, Breast-Sparing,Surgery, Breast Conserving,Surgery, Breast-Sparing
D018270	Carcinoma, Ductal, Breast	An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST.	Carcinoma, Infiltrating Duct,Carcinoma, Invasive Ductal, Breast,Carcinoma, Mammary Ductal,Invasive Ductal Carcinoma, Breast,Mammary Ductal Carcinoma,Carcinomas, Infiltrating Duct,Carcinomas, Mammary Ductal,Mammary Ductal Carcinomas

Related Publications

D J Bolin, and G M Lukas

Dermal angiosarcoma of the breast: a complication of primary radiotherapy?

August 1992, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology,

D J Bolin, and G M Lukas

High-grade cutaneous angiosarcoma of the breast 8.5 years after radiotherapy.

January 2013, The breast journal,

D J Bolin, and G M Lukas

Angiosarcoma of the breast following surgery and radiotherapy for breast cancer.

December 2008, Nature clinical practice. Oncology,

D J Bolin, and G M Lukas

Very low-grade angiosarcoma.

January 1981, Dermatologica,

D J Bolin, and G M Lukas

Case of low-grade primary angiosarcoma of the breast with early recurrence.

May 2019, The breast journal,