Biomaterial Database

Is there still a place for intra-uterine insemination as a treatment for male subfertility? A review. 1995

B J Cohlen, and E R te Velde, and R J van Kooij

Department of Reproductive Medicine, University Hospital Utrecht, The Netherlands.

Using the results of randomized and controlled studies, it was assessed whether there is still a place for intra-uterine insemination (IUI), with or without controlled ovarian hyperstimulation (COH), as a treatment for male subfertility. It is concluded that, in the case of a moderate to severe semen defect, well-timed IUI should be applied in natural cycles only, because COH does not further improve treatment outcome. In contrast, in the case of a mild semen defect, the present evidence indicates that COH improves the probability of conception. If COH is applied, stimulation should be mild in order to prevent multiple pregnancies and the ovarian hyperstimulation syndrome.

UI	MeSH Term	Description	Entries
D007248	Infertility, Male	The inability of the male to effect FERTILIZATION of an OVUM after a specified period of unprotected intercourse. Male sterility is permanent infertility.	Sterility, Male,Sub-Fertility, Male,Subfertility, Male,Male Infertility,Male Sterility,Male Sub-Fertility,Male Subfertility,Sub Fertility, Male
D007315	Insemination, Artificial	Artificial introduction of SEMEN or SPERMATOZOA into the VAGINA to facilitate FERTILIZATION.	Artificial Insemination,Eutelegenesis,Artificial Inseminations,Eutelegeneses,Inseminations, Artificial
D008297	Male		Males
D002986	Clinical Trials as Topic	Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.	Clinical Trial as Topic
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man