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Human Fc gamma receptor IIIA (hFc gamma RIIIA) cDNA was introduced into mouse macrophage/monocyte cell line P388D1, and several stable cell clones expressing hFc gamma RIIIA were isolated. This facilitated the study of the biological function of Fc gamma RIIIA in monocytes/macrophages. The cloned cells showed the high phagocytic activity mediated by hFc gamma-RIIIA, while the original P388D1 cells did not. In order to examine the phosphorylation of proteins involved in hFc gamma RIIIA signal transduction, these receptors were stimulated by cross-linking. The cross-linking of hFc gamma RIIIA induced a rapid increase in tyrosine phosphorylation of several proteins, including PLC-gamma 1, Syk, HS1, and p21rasGAP-associated p190 and p60 proteins. Immunoblotting with a polyclonal antibody specific for the GAP-associated p62 protein, which was originally found in fibroblasts and is homologous with an RNA-binding protein, revealed that the p60 phosphorylated after cross-linking of hFc gamma RIIIA seemed to represent a novel GAP-associated protein unrelated to the known GAP-associated p62 protein, which was also present in the P388D1 cells.
H Zeng, and
T Yoshida, and
T Kurosaki, and
H Yamamura, and
A Oshima, and
D Kitamura, and
T Watanabe, and
M Morikawa
April 1993,
Journal of immunology (Baltimore, Md. : 1950),
H Zeng, and
T Yoshida, and
T Kurosaki, and
H Yamamura, and
A Oshima, and
D Kitamura, and
T Watanabe, and
M Morikawa
June 1994,
Journal of immunology (Baltimore, Md. : 1950),
H Zeng, and
T Yoshida, and
T Kurosaki, and
H Yamamura, and
A Oshima, and
D Kitamura, and
T Watanabe, and
M Morikawa
July 2003,
Journal of neuroimmunology,
H Zeng, and
T Yoshida, and
T Kurosaki, and
H Yamamura, and
A Oshima, and
D Kitamura, and
T Watanabe, and
M Morikawa
September 1996,
The Biochemical journal,
H Zeng, and
T Yoshida, and
T Kurosaki, and
H Yamamura, and
A Oshima, and
D Kitamura, and
T Watanabe, and
M Morikawa
December 1992,
The Journal of experimental medicine,
H Zeng, and
T Yoshida, and
T Kurosaki, and
H Yamamura, and
A Oshima, and
D Kitamura, and
T Watanabe, and
M Morikawa
March 1995,
The Biochemical journal,
H Zeng, and
T Yoshida, and
T Kurosaki, and
H Yamamura, and
A Oshima, and
D Kitamura, and
T Watanabe, and
M Morikawa
January 2004,
Journal of immunology (Baltimore, Md. : 1950),
H Zeng, and
T Yoshida, and
T Kurosaki, and
H Yamamura, and
A Oshima, and
D Kitamura, and
T Watanabe, and
M Morikawa
January 1993,
Journal of immunology (Baltimore, Md. : 1950),
H Zeng, and
T Yoshida, and
T Kurosaki, and
H Yamamura, and
A Oshima, and
D Kitamura, and
T Watanabe, and
M Morikawa
April 1996,
Journal of immunology (Baltimore, Md. : 1950),
H Zeng, and
T Yoshida, and
T Kurosaki, and
H Yamamura, and
A Oshima, and
D Kitamura, and
T Watanabe, and
M Morikawa
August 1995,
Proceedings of the National Academy of Sciences of the United States of America,
