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Because of potential significance of bile acids and cholesterol metabolites in the pathogenesis of colon cancer, fecal neutral sterols, and bile acids were determined in patients with colon cancer, adenomatous polyps or other digestive diseases and American or Japanese controls. The fecal excretion of cholesterol, coprostanol, coprostanone, total bile acids, deoxycholic acid, lithocholic acid was higher in patients with colon cancer and patients with adenomatous polyps compared to normal American and Japanese controls as well as patients with other digestive diseases. Patients with other digestive diseases excreted comparable levels of fecal bile acids and cholesterol metabolites compared to normal American controls; Japanese controls excreted reduced levels compared to normal American controls. These findings suggest that possible interactions between bile acids and cholesterol metabolites and colonic epithelial cells may be relevant in colon carcinogenesis.
B S Reddy, and
E L Wynder
April 1986,
International journal of cancer,
B S Reddy, and
E L Wynder
January 1986,
Digestion,
B S Reddy, and
E L Wynder
January 1982,
Oncology,
B S Reddy, and
E L Wynder
October 1979,
Digestive diseases and sciences,
B S Reddy, and
E L Wynder
January 1992,
Nutrition and cancer,
B S Reddy, and
E L Wynder
April 1988,
Scandinavian journal of gastroenterology,
B S Reddy, and
E L Wynder
January 1983,
Oncology,
B S Reddy, and
E L Wynder
September 1983,
Diseases of the colon and rectum,
B S Reddy, and
E L Wynder
May 1982,
The American journal of gastroenterology,
B S Reddy, and
E L Wynder
January 1972,
Annals of clinical laboratory science,
