-transparent.png){kind=logo}
The ability of optically pure (+)- and (-)-trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene to initiate skin tumors in mice was determined with a two-stage tumorigenesis system. A single application of 50 to 200 nmoles of (+)- or (-)-trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene to the backs of CD-1 mice followed by twice-weekly applications of 12-O-tetradecanoyl-phorbol-13-acetate revealed that the (-)-enantiomer was 5- to 10-fold more potent than was the (+)-enantiomer as a tumor initiator at the three dosage levels tested. When the tumor-initiating activities of the (+)0 and (-)-enantiomers of trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene were compared to the activity of benzo(a)pyrene at an equimolar dose, the (-)-enantiomer was more active while the (+)-enantiomer was considerably less active. This is the first report of differences in the carcinogenic activity between optical enantiomers.
W Levin, and
A W Wood, and
R L Chang, and
T J Slaga, and
H Yagi, and
D M Jerina, and
A H Conney
September 1978,
Cancer research,
W Levin, and
A W Wood, and
R L Chang, and
T J Slaga, and
H Yagi, and
D M Jerina, and
A H Conney
November 1978,
Mutation research,
W Levin, and
A W Wood, and
R L Chang, and
T J Slaga, and
H Yagi, and
D M Jerina, and
A H Conney
May 1980,
Biochemical and biophysical research communications,
W Levin, and
A W Wood, and
R L Chang, and
T J Slaga, and
H Yagi, and
D M Jerina, and
A H Conney
May 1978,
Cancer research,
W Levin, and
A W Wood, and
R L Chang, and
T J Slaga, and
H Yagi, and
D M Jerina, and
A H Conney
August 1979,
Cancer research,
W Levin, and
A W Wood, and
R L Chang, and
T J Slaga, and
H Yagi, and
D M Jerina, and
A H Conney
October 1976,
Proceedings of the National Academy of Sciences of the United States of America,
W Levin, and
A W Wood, and
R L Chang, and
T J Slaga, and
H Yagi, and
D M Jerina, and
A H Conney
May 1980,
Biochemical and biophysical research communications,
W Levin, and
A W Wood, and
R L Chang, and
T J Slaga, and
H Yagi, and
D M Jerina, and
A H Conney
January 1992,
Chemical research in toxicology,
W Levin, and
A W Wood, and
R L Chang, and
T J Slaga, and
H Yagi, and
D M Jerina, and
A H Conney
November 1995,
Carcinogenesis,
W Levin, and
A W Wood, and
R L Chang, and
T J Slaga, and
H Yagi, and
D M Jerina, and
A H Conney
June 1980,
The Journal of biological chemistry,
