-transparent.png){kind=logo}
The dispositions of vancomycin (VCM) and gentamicin (GM) in plasma and perilymph after single and multiple administrations and the effects of multiple administrations of VCM or GM alone and the combination of both drugs on auditory function were studied in male guinea pigs. The pharmacokinetic parameters of VCM and GM obtained from plasma drug concentration-time data after single and multiple (22 days) intramuscular administrations of VCM (200 mg/kg of body weight) alone and GM (50 mg/kg) alone were not significantly different from those after combined administration of VCM (200 mg/kg) and GM (50 mg/kg). There was no change in the penetration ratio of VCM and GM into perilymph between administration of VCM or GM alone and the combination of both drugs. Furthermore, the hearing threshold of guinea pigs was not affected by VCM or GM alone or the combination of both drugs within the range of therapeutic VCM and GM levels in plasma in humans.
K Nishihara, and
T Shimizu, and
H Kotaki, and
Y Sawada, and
T Okuno, and
K Kaga, and
T Murofushi, and
T Iga
January 1990,
Archives of otolaryngology--head & neck surgery,
K Nishihara, and
T Shimizu, and
H Kotaki, and
Y Sawada, and
T Okuno, and
K Kaga, and
T Murofushi, and
T Iga
January 1996,
Zhonghua er bi yan hou ke za zhi,
K Nishihara, and
T Shimizu, and
H Kotaki, and
Y Sawada, and
T Okuno, and
K Kaga, and
T Murofushi, and
T Iga
March 1951,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
K Nishihara, and
T Shimizu, and
H Kotaki, and
Y Sawada, and
T Okuno, and
K Kaga, and
T Murofushi, and
T Iga
January 1987,
Antimicrobial agents and chemotherapy,
K Nishihara, and
T Shimizu, and
H Kotaki, and
Y Sawada, and
T Okuno, and
K Kaga, and
T Murofushi, and
T Iga
February 2007,
Neurobiology of disease,
K Nishihara, and
T Shimizu, and
H Kotaki, and
Y Sawada, and
T Okuno, and
K Kaga, and
T Murofushi, and
T Iga
August 2000,
Toxicology and applied pharmacology,
K Nishihara, and
T Shimizu, and
H Kotaki, and
Y Sawada, and
T Okuno, and
K Kaga, and
T Murofushi, and
T Iga
June 1992,
Nihon Jibiinkoka Gakkai kaiho,
K Nishihara, and
T Shimizu, and
H Kotaki, and
Y Sawada, and
T Okuno, and
K Kaga, and
T Murofushi, and
T Iga
January 1987,
Hearing research,
K Nishihara, and
T Shimizu, and
H Kotaki, and
Y Sawada, and
T Okuno, and
K Kaga, and
T Murofushi, and
T Iga
May 2006,
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology,
K Nishihara, and
T Shimizu, and
H Kotaki, and
Y Sawada, and
T Okuno, and
K Kaga, and
T Murofushi, and
T Iga
May 1995,
Acta oto-laryngologica,
