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Four normal subjects on a free sodium intake received intravenous isoprenaline in doses of 2, 4, 8 and 16 microgram over 2 min. Three of the subjects received a second infusion of 8 microgram. The rate of renin release indexed by changes in plasma renin activity increased in all subjects at each dose level. The mean peak levels of plasma renin were 9%, 29% and 77% above the mean control levels at doses of 2, 4 and 8 microgram respectively. The response of 16 microgram was no different from that seen with 8 microgram. The renin response obtained at 8 microgram was highly reproducible such that the coefficient of variation for duplicate estimations of plasma renin (twelve duplicates) ranged from 1.7 to 4%.
R Davies, and
J D Slater, and
M Rudolf, and
D M Geddes
November 1969,
Circulation research,
R Davies, and
J D Slater, and
M Rudolf, and
D M Geddes
July 1979,
International journal of clinical pharmacology and biopharmacy,
R Davies, and
J D Slater, and
M Rudolf, and
D M Geddes
October 1976,
Lancet (London, England),
R Davies, and
J D Slater, and
M Rudolf, and
D M Geddes
January 1976,
Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association,
R Davies, and
J D Slater, and
M Rudolf, and
D M Geddes
December 1975,
The Journal of clinical endocrinology and metabolism,
R Davies, and
J D Slater, and
M Rudolf, and
D M Geddes
May 1972,
The Journal of clinical endocrinology and metabolism,
R Davies, and
J D Slater, and
M Rudolf, and
D M Geddes
January 1970,
Annales medicinae experimentalis et biologiae Fenniae,
R Davies, and
J D Slater, and
M Rudolf, and
D M Geddes
November 1975,
Clinical science and molecular medicine,
R Davies, and
J D Slater, and
M Rudolf, and
D M Geddes
January 1976,
Nephron,
R Davies, and
J D Slater, and
M Rudolf, and
D M Geddes
February 1972,
The Journal of clinical endocrinology and metabolism,
