Biomaterial Database

Coronary circulatory effects of increased intrathoracic pressure in intact dogs. 1977

C J Pepine

The effect of increased intrathoracic pressure on coronary hemodynamics and coronary venous oxygen tension was evaluated in surgically instrumented dogs. Following abrupt increase in intrathoracic pressure, as systolic pressure decrease, the tension time index (TTI) fell 83 percent (P less than 0.001) compared to control. The diastolic pressure time index (DPTI) decline proportionately less, effecting an increase in the ratio of DPTI/TTI from 1.19 +/- 0.08 to 1.78 +/- 0.16 (P LESS THAN 0.05). The mean circumflex coronary blood flow declined only minimally toward the end of the test (5.1 +/- 9.0 ml/min; P less than 0.05), and stroke systolic circumflex coronary blood flow increased 116 percent (P less than 0.01) as late diastolic coronary resistance decreased 31 percent (P less than 0.01). The mean coronary venous oxygen pressure increased transiently above control values from 21 +/- 1 to 24 +/- 2 mm Hg (P less than 0.05). These data suggest that in anesthetized dogs, brief periods of high intrathoracic pressure abruptly reduce determinants of myocardial demand for oxygen, while myocardial perfusion decreases to a lesser degree.

UI	MeSH Term	Description	Entries
D008954	Models, Biological	Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.	Biological Model,Biological Models,Model, Biological,Models, Biologic,Biologic Model,Biologic Models,Model, Biologic
D011312	Pressure	A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)	Pressures
D001775	Blood Circulation	The movement of the BLOOD as it is pumped through the CARDIOVASCULAR SYSTEM.	Blood Flow,Circulation, Blood,Blood Flows,Flow, Blood
D001794	Blood Pressure	PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.	Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D002302	Cardiac Output	The volume of BLOOD passing through the HEART per unit of time. It is usually expressed as liters (volume) per minute so as not to be confused with STROKE VOLUME (volume per beat).	Cardiac Outputs,Output, Cardiac,Outputs, Cardiac
D003326	Coronary Circulation	The circulation of blood through the CORONARY VESSELS of the HEART.	Circulation, Coronary
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D006439	Hemodynamics	The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.	Hemodynamic
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001011	Aorta	The main trunk of the systemic arteries.	Aortas