-transparent.png){kind=logo}
TGF-beta has been shown to be one of the most important regulators in chondrogenesis and osteogenesis. Daily subperiosteal injection of TGF-beta, which was extracted and purified from bovine platelets, into adult mouse femur resulted in proliferation and differentiation of the mesenchymal cells, chondrogenesis, and endochondral osteogenesis. After cessation of the injection, the endochondral ossification occurred widely, resulting in replacement of the cartilage with new bone. These phenomena demonstrate that exogenous TGF-beta stimulates mesenchymal proliferation and differentiation that occur in early fracture healing and suggest the possibility of clinical application of TGF-beta for fracture repair and bone transplantation.
Y Sun, and
Y Lu, and
Y Hu, and
F Ma, and
W Chen
March 1998,
The international journal of biochemistry & cell biology,
Y Sun, and
Y Lu, and
Y Hu, and
F Ma, and
W Chen
October 1990,
Sheng li ke xue jin zhan [Progress in physiology],
Y Sun, and
Y Lu, and
Y Hu, and
F Ma, and
W Chen
October 1991,
Molecular endocrinology (Baltimore, Md.),
Y Sun, and
Y Lu, and
Y Hu, and
F Ma, and
W Chen
October 1996,
American journal of respiratory and critical care medicine,
Y Sun, and
Y Lu, and
Y Hu, and
F Ma, and
W Chen
February 1998,
Journal of immunoassay,
Y Sun, and
Y Lu, and
Y Hu, and
F Ma, and
W Chen
June 1990,
The Journal of cell biology,
Y Sun, and
Y Lu, and
Y Hu, and
F Ma, and
W Chen
April 2004,
British journal of plastic surgery,
Y Sun, and
Y Lu, and
Y Hu, and
F Ma, and
W Chen
September 2005,
Autoimmunity reviews,
Y Sun, and
Y Lu, and
Y Hu, and
F Ma, and
W Chen
October 1993,
Clinical and experimental immunology,
Y Sun, and
Y Lu, and
Y Hu, and
F Ma, and
W Chen
June 2000,
The Journal of biological chemistry,
