In vitro inhibition of catalase by 4-hydroxypyrazole, a metabolite of pyrazole.
1977
F H Deis, and
G W Lin, and
D Lester
UI
MeSH Term
Description
Entries
D007700
Kinetics
The rate dynamics in chemical or physical systems.
D011720
Pyrazoles
Azoles of two nitrogens at the 1,2 positions, next to each other, in contrast with IMIDAZOLES in which they are at the 1,3 positions.
D002374
Catalase
An oxidoreductase that catalyzes the conversion of HYDROGEN PEROXIDE to water and oxygen. It is present in many animal cells. A deficiency of this enzyme results in ACATALASIA.
A non-selective post-emergence, translocated herbicide. According to the Seventh Annual Report on Carcinogens (PB95-109781, 1994) this substance may reasonably be anticipated to be a carcinogen. (From Merck Index, 12th ed) It is an irreversible inhibitor of CATALASE, and thus impairs activity of peroxisomes.