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OBJECTIVE We compared the efficacy of interferon and deflazacort in the treatment of the cryoglobulinaemic syndrome and assessed the usefulness of adding a low antigen diet to drug therapy. METHODS We studied 63 patients randomly allocated to different groups who underwent clinical and laboratory examinations every two months and who received treatment for 12 months or until a significant clinical event appeared. RESULTS Five of 28 patients treated with interferon showed clinical improvement whereas 4 worsened and 7 suffered untoward side effects; seven of 28 patients treated with deflazacort improved, 4 worsened and 4 suffered drug toxicity. Twenty-nine patients were assigned to combined low antigen diet and therapy, among whom 7 did not follow the diet, 5 improved and 2 worsened. Among the 34 patients who were on an unrestrained diet, 5 improved and 7 worsened. None of the treatments proved superior to the others. CONCLUSIONS Our results do not confirm the suggestion that interferon should be the primary therapy in the treatment of the cryoglobulinaemic syndrome, and the usefulness of a low antigen diet seems minimal.
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P Maldifassi, and
A Vacca, and
C Mazzaro, and
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S Migliaresi, and
A Gabrielli, and
M Pietrogrande, and
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G Monti
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European journal of haematology,
P Pioltelli, and
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A Vacca, and
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S Migliaresi, and
A Gabrielli, and
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A Monteverde, and
G Monti
January 1985,
Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress,
P Pioltelli, and
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March 1986,
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February 1992,
Journal of neurology, neurosurgery, and psychiatry,
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April 1978,
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P Pioltelli, and
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January 1979,
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August 1993,
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January 1993,
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P Pioltelli, and
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May 1980,
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P Pioltelli, and
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February 1992,
The Quarterly journal of medicine,
