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Nitric oxide is widely recognized as a putative retrograde messenger in the brain. We infused NG-monomethyl-L-arginine (L-NMMA; 25 mg/kg), an inhibitor of nitric oxide synthase (NOS), continuously for a week into the dorsal third ventricle (D3V) of spontaneous hypertensive rate (SHR) by an osmotic infusion pump. Rats administered with L-NMMA showed impaired performance of a radial arm maze task compared with control rats administered with saline. We observed significant reductions of the NOx level in the cerebrospinal fluid (CSF) of the rats administered with L-NMMA, but not in the control rats. Both groups showed no change in systolic blood pressure or serum NOx level. The results provide evidence of a more specific effect of NOS inhibition to the brain independent of alterations in the systemic hemodynamics.
Y Suzuki, and
H Ikari, and
T Hayashi, and
A Iguchi
May 1996,
Neurobiology of learning and memory,
Y Suzuki, and
H Ikari, and
T Hayashi, and
A Iguchi
October 2011,
Behavioural brain research,
Y Suzuki, and
H Ikari, and
T Hayashi, and
A Iguchi
March 2001,
Brain research,
Y Suzuki, and
H Ikari, and
T Hayashi, and
A Iguchi
September 2008,
Neurobiology of learning and memory,
Y Suzuki, and
H Ikari, and
T Hayashi, and
A Iguchi
January 1997,
Journal of biomedical science,
Y Suzuki, and
H Ikari, and
T Hayashi, and
A Iguchi
October 2007,
Pharmacology, biochemistry, and behavior,
Y Suzuki, and
H Ikari, and
T Hayashi, and
A Iguchi
May 2022,
Bulletin of experimental biology and medicine,
Y Suzuki, and
H Ikari, and
T Hayashi, and
A Iguchi
May 2012,
Brain research,
Y Suzuki, and
H Ikari, and
T Hayashi, and
A Iguchi
August 2003,
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology,
Y Suzuki, and
H Ikari, and
T Hayashi, and
A Iguchi
October 1993,
Proceedings of the National Academy of Sciences of the United States of America,
