-transparent.png){kind=logo}
A Japanese infant with a severe neonatal form of nemaline myopathy showed features of muscle immaturity as well as rods in the biopsied quadriceps femoris muscle, and involvement of diaphragm was first confirmed at autopsy. The biopsied muscle showed numerous rods in 80% of muscle fibers, and an increased number of type 2C fibers (23.2%). Electron microscopic findings were characterized by the presence of many small, immature round fibers with central nuclei and sparse myofibrils, and an increased number of satellite cells in close association with the small muscle fibers, as well as numerous rod structures. These microscopic and electron microscopic findings are interpreted as immature muscle fibers. Maturational delay or arrest implies deprivation of a development promoting factor such as a neuronal signal. Severe involvement with numerous rods was demonstrated in both diaphragm and intercostal muscles at the time of the postmortem examination, compatible with the patient's respiratory failure.
H Wada, and
H Nishio, and
M Kugo, and
S Waku, and
K Ikeda, and
S Takada, and
R Murakami, and
H Itoh, and
M Matsuo, and
H Nakamura
November 1987,
Archives francaises de pediatrie,
H Wada, and
H Nishio, and
M Kugo, and
S Waku, and
K Ikeda, and
S Takada, and
R Murakami, and
H Itoh, and
M Matsuo, and
H Nakamura
September 1982,
Acta pathologica japonica,
H Wada, and
H Nishio, and
M Kugo, and
S Waku, and
K Ikeda, and
S Takada, and
R Murakami, and
H Itoh, and
M Matsuo, and
H Nakamura
March 1990,
Archives francaises de pediatrie,
H Wada, and
H Nishio, and
M Kugo, and
S Waku, and
K Ikeda, and
S Takada, and
R Murakami, and
H Itoh, and
M Matsuo, and
H Nakamura
January 2001,
Ryoikibetsu shokogun shirizu,
H Wada, and
H Nishio, and
M Kugo, and
S Waku, and
K Ikeda, and
S Takada, and
R Murakami, and
H Itoh, and
M Matsuo, and
H Nakamura
January 1998,
Journal of pediatric ophthalmology and strabismus,
H Wada, and
H Nishio, and
M Kugo, and
S Waku, and
K Ikeda, and
S Takada, and
R Murakami, and
H Itoh, and
M Matsuo, and
H Nakamura
January 1994,
Neuromuscular disorders : NMD,
H Wada, and
H Nishio, and
M Kugo, and
S Waku, and
K Ikeda, and
S Takada, and
R Murakami, and
H Itoh, and
M Matsuo, and
H Nakamura
January 1989,
Pediatric neurology,
H Wada, and
H Nishio, and
M Kugo, and
S Waku, and
K Ikeda, and
S Takada, and
R Murakami, and
H Itoh, and
M Matsuo, and
H Nakamura
April 1992,
Acta paediatrica Japonica : Overseas edition,
H Wada, and
H Nishio, and
M Kugo, and
S Waku, and
K Ikeda, and
S Takada, and
R Murakami, and
H Itoh, and
M Matsuo, and
H Nakamura
April 1990,
Journal of child neurology,
H Wada, and
H Nishio, and
M Kugo, and
S Waku, and
K Ikeda, and
S Takada, and
R Murakami, and
H Itoh, and
M Matsuo, and
H Nakamura
June 2009,
Muscle & nerve,
