Biomaterial Database

Effect of hyperthermia on glucose homeostasis in young dogs. An experimental study. 1977

S A Omar, and S A Rizvi, and S Varma

Hyperthermia was produced in healthy anaesthetized young dogs by keeping them in a theromostatically controlled chamber, and the effects on blood glucose concentration were studies. The blood glucose levels decreased significantly at body temperatures of 40.5 degrees C and 42.5 degrees C. The decrease was greater at the latter temperature. Intravenous glucose tolerance tests were performed to study the rates of glucose utilization during hyperthermia. The calculated fractional rates of disappearance of glucose (Kt values) were found to be significantly higher in dogs having a body temperature of 42.4 degrees C. The cause of hypoglycemia produced at high body temperature seems to be due to an elevated insulin secretion which increases the over all utilization of glucose by the peripheral tissues. The study of time course of hyperglycemic response following intravenous glucose tolerance tests performed at high body temperature further support the possibility of an increase in insulin secretion in dogs subjected to hyperthermia.

UI	MeSH Term	Description	Entries
D007275	Injections, Intravenous	Injections made into a vein for therapeutic or experimental purposes.	Intravenous Injections,Injection, Intravenous,Intravenous Injection
D008297	Male		Males
D001786	Blood Glucose	Glucose in blood.	Blood Sugar,Glucose, Blood,Sugar, Blood
D001831	Body Temperature	The measure of the level of heat of a human or animal.	Organ Temperature,Body Temperatures,Organ Temperatures,Temperature, Body,Temperature, Organ,Temperatures, Body,Temperatures, Organ
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D005260	Female		Females
D005947	Glucose	A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.	Dextrose,Anhydrous Dextrose,D-Glucose,Glucose Monohydrate,Glucose, (DL)-Isomer,Glucose, (alpha-D)-Isomer,Glucose, (beta-D)-Isomer,D Glucose,Dextrose, Anhydrous,Monohydrate, Glucose
D006358	Hot Temperature	Presence of warmth or heat or a temperature notably higher than an accustomed norm.	Heat,Hot Temperatures,Temperature, Hot,Temperatures, Hot
D006706	Homeostasis	The processes whereby the internal environment of an organism tends to remain balanced and stable.	Autoregulation
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia