-transparent.png){kind=logo}
Pulmonary venous flow velocity recordings have been found to be useful in complementing the information obtained from the mitral flow velocity and improving the assessment of left ventricular diastolic pressures. This study was undertaken to evaluate the accuracy of mitral flow and pulmonary venous flow variables, recorded by transthoracic Doppler echocardiography, in estimating left ventricular end-diastolic pressure (LVEDP) in 101 consecutive patients with coronary artery disease undergoing diagnostic left-sided heart catheterization. Patients were assigned to three groups according to the values of LVEDP (group 1, < or = 12 mm Hg; group 2, between 13 and 19 mm Hg; and group 3, > or = 20 mm Hg). LVEDP correlated most strongly with systolic fraction of pulmonary venous flow (r = -0.76), isovolumic relaxation time (r = -0.76), E/A ratio (r = 0.74), deceleration time of early mitral flow (r = -0.74), and mitral A wave duration/pulmonary venous A wave duration (AD/PVAD) ratio (r = -0.70) (p < 0.01 for each correlation). Discriminant analysis demonstrated that deceleration time, AD/PVAD ratio, and isovolumic relaxation time were major determinants of LVEDP, with 87.1% of patients correctly assigned to study groups; 97% of patients of group 1 and 95% of patients of group 3 were identified, whereas the accuracy in identifying the patients of group 2 was lower (41%). Deceleration times of 140 msec or less and AD/PVAD ratios of 0.9 or less were the best cutoff points in predicting an LVEDP of 20 mm Hg or greater. Multiple linear regression analysis demonstrated that the combination of mitral flow and pulmonary venous flow velocity variables provided a better estimation of LVEDP compared with that obtained from mitral flow velocity recordings alone (r = 0.88 versus 0.79; F test, 20.6). We conclude that combined analysis of mitral flow and pulmonary venous flow velocity provides, in patients with coronary artery disease, a noninvasive estimation of LVEDP with an accurate prediction of pressures of 12 mm Hg or less and 20 mm Hg or greater and less accurate prediction of intermediate values.
M Cecconi, and
M Manfrin, and
R Zanoli, and
P Colonna, and
O Ruga, and
A Pangrazi, and
A Soro
March 1993,
The European journal of medicine,
M Cecconi, and
M Manfrin, and
R Zanoli, and
P Colonna, and
O Ruga, and
A Pangrazi, and
A Soro
January 1995,
Acta cardiologica,
M Cecconi, and
M Manfrin, and
R Zanoli, and
P Colonna, and
O Ruga, and
A Pangrazi, and
A Soro
September 1995,
International journal of cardiac imaging,
M Cecconi, and
M Manfrin, and
R Zanoli, and
P Colonna, and
O Ruga, and
A Pangrazi, and
A Soro
July 2002,
American journal of physiology. Heart and circulatory physiology,
M Cecconi, and
M Manfrin, and
R Zanoli, and
P Colonna, and
O Ruga, and
A Pangrazi, and
A Soro
November 1988,
The American journal of cardiology,
M Cecconi, and
M Manfrin, and
R Zanoli, and
P Colonna, and
O Ruga, and
A Pangrazi, and
A Soro
August 1970,
Minnesota medicine,
M Cecconi, and
M Manfrin, and
R Zanoli, and
P Colonna, and
O Ruga, and
A Pangrazi, and
A Soro
November 1991,
Chinese medical journal,
M Cecconi, and
M Manfrin, and
R Zanoli, and
P Colonna, and
O Ruga, and
A Pangrazi, and
A Soro
January 1992,
Postgraduate medical journal,
M Cecconi, and
M Manfrin, and
R Zanoli, and
P Colonna, and
O Ruga, and
A Pangrazi, and
A Soro
June 1988,
Zhonghua xin xue guan bing za zhi,
M Cecconi, and
M Manfrin, and
R Zanoli, and
P Colonna, and
O Ruga, and
A Pangrazi, and
A Soro
July 1983,
American heart journal,
