BIOMAT Database Logo BIOMAT Database Logo

Clinical significance of carcinoma invasion of the extrapancreatic nerve plexus in pancreatic cancer. 1996

A Nakao, and A Harada, and T Nonami, and T Kaneko, and H Takagi
Department of Surgery II, Nagoya University School of Medicine, Japan.

To elucidate the clinical significance of neural invasion in pancreatic carcinoma, a clinicopathological study was performed. Neural invasion is a common feature of pancreatic carcinoma whose clinical significance has not yet been determined. Over a period of > 10 years, 129 of 204 (63%) patients with pancreatic carcinoma underwent resection by extensive radical surgery. A clinicopathological study of those specimens of pancreatic carcinoma was performed, with particular reference to neural invasion. Intrapancreatic neural invasion was observed in 116 of 129 (90%), of which 80 (69%) showed extrapancreatic nerve plexus involvement. A statistically significant (p < 0.001) correlation between the grade of intrapancreatic neural invasion and extrapancreatic nerve plexus invasion was observed. The postoperative survival rate for patients with extrapancreatic nerve plexus involvement was significantly (p < 0.001) lower than that for patients without extrapancreatic nerve plexus involvement. Patients who survived for > 3 years after operation had no extrapancreatic nerve plexus invasion even when portal vein wall invasion was observed.

UI MeSH Term Description Entries
D008207 Lymphatic Metastasis Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system. Lymph Node Metastasis,Lymph Node Metastases,Lymphatic Metastases,Metastasis, Lymph Node
D009361 Neoplasm Invasiveness Ability of neoplasms to infiltrate and actively destroy surrounding tissue. Invasiveness, Neoplasm,Neoplasm Invasion,Invasion, Neoplasm
D009362 Neoplasm Metastasis The transfer of a neoplasm from one organ or part of the body to another remote from the primary site. Metastase,Metastasis,Metastases, Neoplasm,Metastasis, Neoplasm,Neoplasm Metastases,Metastases
D010179 Pancreas A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.
D010190 Pancreatic Neoplasms Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA). Cancer of Pancreas,Pancreatic Cancer,Cancer of the Pancreas,Neoplasms, Pancreatic,Pancreas Cancer,Pancreas Neoplasms,Pancreatic Acinar Carcinoma,Pancreatic Carcinoma,Acinar Carcinoma, Pancreatic,Acinar Carcinomas, Pancreatic,Cancer, Pancreas,Cancer, Pancreatic,Cancers, Pancreas,Cancers, Pancreatic,Carcinoma, Pancreatic,Carcinoma, Pancreatic Acinar,Carcinomas, Pancreatic,Carcinomas, Pancreatic Acinar,Neoplasm, Pancreas,Neoplasm, Pancreatic,Neoplasms, Pancreas,Pancreas Cancers,Pancreas Neoplasm,Pancreatic Acinar Carcinomas,Pancreatic Cancers,Pancreatic Carcinomas,Pancreatic Neoplasm
D011169 Portal Vein A short thick vein formed by union of the superior mesenteric vein and the splenic vein. Portal Veins,Vein, Portal,Veins, Portal
D011379 Prognosis A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations. Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D002277 Carcinoma A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for "cancer." Carcinoma, Anaplastic,Carcinoma, Spindle-Cell,Carcinoma, Undifferentiated,Carcinomatosis,Epithelial Neoplasms, Malignant,Epithelioma,Epithelial Tumors, Malignant,Malignant Epithelial Neoplasms,Neoplasms, Malignant Epithelial,Anaplastic Carcinoma,Anaplastic Carcinomas,Carcinoma, Spindle Cell,Carcinomas,Carcinomatoses,Epithelial Neoplasm, Malignant,Epithelial Tumor, Malignant,Epitheliomas,Malignant Epithelial Neoplasm,Malignant Epithelial Tumor,Malignant Epithelial Tumors,Neoplasm, Malignant Epithelial,Spindle-Cell Carcinoma,Spindle-Cell Carcinomas,Tumor, Malignant Epithelial,Undifferentiated Carcinoma,Undifferentiated Carcinomas
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

A Nakao, and A Harada, and T Nonami, and T Kaneko, and H Takagi
Clinical significance of intraportal endovascular ultrasonography for the diagnosis of extrapancreatic nerve plexus invasion by pancreatic carcinoma.
January 2004, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.],
A Nakao, and A Harada, and T Nonami, and T Kaneko, and H Takagi
Clinicopathological study on neural invasion to the extrapancreatic nerve plexus in pancreatic cancer.
February 1992, Hepato-gastroenterology,
A Nakao, and A Harada, and T Nonami, and T Kaneko, and H Takagi
CT and MR imaging patterns for pancreatic carcinoma invading the extrapancreatic neural plexus (Part II): Imaging of pancreatic carcinoma nerve invasion.
January 2012, World journal of radiology,
A Nakao, and A Harada, and T Nonami, and T Kaneko, and H Takagi
Extrapancreatic neural plexus invasion by pancreatic carcinoma: characteristics on magnetic resonance imaging.
January 2009, Abdominal imaging,
A Nakao, and A Harada, and T Nonami, and T Kaneko, and H Takagi
Pancreaticoduodenectomy with right-oblique posterior dissection of superior mesenteric nerve plexus is logical procedure for pancreatic cancer with extrapancreatic nerve plexus invasion.
January 2014, Hepato-gastroenterology,
A Nakao, and A Harada, and T Nonami, and T Kaneko, and H Takagi
Extrapancreatic Nerve Plexus Invasion on Imaging Predicts Poor Survival After Upfront Surgery for Anatomically Resectable Pancreatic Cancer.
January 2020, Pancreas,
A Nakao, and A Harada, and T Nonami, and T Kaneko, and H Takagi
Impact of resection margin status on survival after operation for pancreatic head cancer with extrapancreatic nerve plexus invasion.
November 2022, Journal of surgical oncology,
A Nakao, and A Harada, and T Nonami, and T Kaneko, and H Takagi
Clinicopathological study of pancreatic carcinoma with particular reference to the invasion of the extrapancreatic neural plexus.
October 1991, International journal of pancreatology : official journal of the International Association of Pancreatology,
A Nakao, and A Harada, and T Nonami, and T Kaneko, and H Takagi
Detection of extrapancreatic nerve plexus invasion of pancreatic adenocarcinoma. Cytokeratin 19 staining and K-ras mutation.
December 1999, International journal of pancreatology : official journal of the International Association of Pancreatology,
A Nakao, and A Harada, and T Nonami, and T Kaneko, and H Takagi
CT and MR imaging patterns for pancreatic carcinoma invading the extrapancreatic neural plexus (Part I): Anatomy, imaging of the extrapancreatic nerve.
February 2012, World journal of radiology,
Copied contents to your clipboard!