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This study was undertaken to determine the effect of somatostatin on acute, orciprenaline mediated, beta-adrenergic stimulation of free fatty acids, blood glucose, insulin, and glucagon in healthy subjects. After orciprenaline and somatostatin insulin and glucagon decreased, whereas blood glucose and free fatty acids increased, probably in part as a result of the lesser inhibition of glucagon (50%) than of insulin (83%). From these observations it is tentatively concluded that the inhibitory effects of somatostatin on insulin and glucagon release in man are a consequence of beta-adrenergic receptor involvement. These effects are possibly mediated through increased destruction of cAMP, blocking of camp dependent secretion or impairment of calcium uptake.
S Raptis, and
F Escobar-Jimenez, and
J Rosenthal, and
H H Ditschuneit, and
E F Pfeiffer
August 1984,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
S Raptis, and
F Escobar-Jimenez, and
J Rosenthal, and
H H Ditschuneit, and
E F Pfeiffer
February 1974,
Circulation,
S Raptis, and
F Escobar-Jimenez, and
J Rosenthal, and
H H Ditschuneit, and
E F Pfeiffer
February 1979,
The Journal of clinical endocrinology and metabolism,
S Raptis, and
F Escobar-Jimenez, and
J Rosenthal, and
H H Ditschuneit, and
E F Pfeiffer
August 1969,
European journal of pharmacology,
S Raptis, and
F Escobar-Jimenez, and
J Rosenthal, and
H H Ditschuneit, and
E F Pfeiffer
February 1979,
The Journal of clinical investigation,
S Raptis, and
F Escobar-Jimenez, and
J Rosenthal, and
H H Ditschuneit, and
E F Pfeiffer
March 1988,
The American journal of physiology,
S Raptis, and
F Escobar-Jimenez, and
J Rosenthal, and
H H Ditschuneit, and
E F Pfeiffer
January 1986,
Comparative biochemistry and physiology. A, Comparative physiology,
S Raptis, and
F Escobar-Jimenez, and
J Rosenthal, and
H H Ditschuneit, and
E F Pfeiffer
January 1982,
Journal of endocrinological investigation,
S Raptis, and
F Escobar-Jimenez, and
J Rosenthal, and
H H Ditschuneit, and
E F Pfeiffer
March 1984,
Acta physiologica Scandinavica,
S Raptis, and
F Escobar-Jimenez, and
J Rosenthal, and
H H Ditschuneit, and
E F Pfeiffer
September 1990,
Metabolism: clinical and experimental,
