-transparent.png){kind=logo}
BACKGROUND The incidence of second malignancies is markedly increased following transplantation of solid organs. However, the development of Hodgkin's disease has been described relatively infrequently in this setting, and there is little clinical information on these patients and few details on management. METHODS We have reviewed the pathologic specimens and clinical history of four patients who developed Hodgkin's disease following transplantation of solid organs. RESULTS Hodgkin's disease appeared 26-68 months following transplantation of the kidney (2 cases), liver, and heart. Three cases demonstrated evidence of Epstein-Barr virus (EBV) in Reed-Sternberg cells. One case appears to have arisen after a previous EBV-driven polymorphous lymphoproliferation. Hodgkin's disease was localized in three cases and disseminated in one. All patients achieved remission with standard therapy and continue in remission between 9 and 61 months after therapy. Graft function was preserved in all patients. CONCLUSIONS Hodgkin's disease occurring in the post-transplantation period should probably be treated like Hodgkin's disease in non-immunosuppressed patients. Prolonged disease-free survival is possible and function of the transplanted organ can be preserved.
P J Bierman, and
J M Vose, and
A N Langnas, and
R M Rifkin, and
R J Hauke, and
B N Smir, and
T C Greiner
September 2008,
Clinical immunology (Orlando, Fla.),
P J Bierman, and
J M Vose, and
A N Langnas, and
R M Rifkin, and
R J Hauke, and
B N Smir, and
T C Greiner
January 2007,
Transplantation proceedings,
P J Bierman, and
J M Vose, and
A N Langnas, and
R M Rifkin, and
R J Hauke, and
B N Smir, and
T C Greiner
April 2010,
Transplant infectious disease : an official journal of the Transplantation Society,
P J Bierman, and
J M Vose, and
A N Langnas, and
R M Rifkin, and
R J Hauke, and
B N Smir, and
T C Greiner
August 2014,
Current opinion in infectious diseases,
P J Bierman, and
J M Vose, and
A N Langnas, and
R M Rifkin, and
R J Hauke, and
B N Smir, and
T C Greiner
September 2002,
Transplantation proceedings,
P J Bierman, and
J M Vose, and
A N Langnas, and
R M Rifkin, and
R J Hauke, and
B N Smir, and
T C Greiner
January 2001,
Transplantation proceedings,
P J Bierman, and
J M Vose, and
A N Langnas, and
R M Rifkin, and
R J Hauke, and
B N Smir, and
T C Greiner
February 2002,
Pediatric transplantation,
P J Bierman, and
J M Vose, and
A N Langnas, and
R M Rifkin, and
R J Hauke, and
B N Smir, and
T C Greiner
February 2019,
The Surgical clinics of North America,
P J Bierman, and
J M Vose, and
A N Langnas, and
R M Rifkin, and
R J Hauke, and
B N Smir, and
T C Greiner
January 2019,
Critical care clinics,
P J Bierman, and
J M Vose, and
A N Langnas, and
R M Rifkin, and
R J Hauke, and
B N Smir, and
T C Greiner
June 2012,
Orvosi hetilap,
