Biomaterial Database

Age-related production of new granule cells in the adult dentate gyrus. 1995

T Seki, and Y Arai

Department of Anatomy, Juntendo University School of Medicine, Tokyo, Japan.

Unlike most neurones, the dentate granule cells continue to be produced in adults. Recently our study has demonstrated that a highly polysialylated neural cell adhesion molecule (NCAM-H) is a reliable molecular marker for newly generated and developing dentate granule cells. Here we examined age-related changes in the number of newly generated and developing granule cells. In rats injected with 5-bromo-2'-deoxyuridine (BrdU), a thymidine analogue, at 35 days to 18 months of age, double immunohistochemistry for BrdU and NCAM-H showed that the numbers of NCAM-H-positive and BrdU-/NCAM-H-positive granule cells gradually decreased over more than one year, but they were still detected in 18-month-old rats. These findings indicate that newly formed and developing granule cells occur in the dentate gyrus of young and aged rats, but the number of these cells decreases with age.

UI	MeSH Term	Description	Entries
D007150	Immunohistochemistry	Histochemical localization of immunoreactive substances using labeled antibodies as reagents.	Immunocytochemistry,Immunogold Techniques,Immunogold-Silver Techniques,Immunohistocytochemistry,Immunolabeling Techniques,Immunogold Technics,Immunogold-Silver Technics,Immunolabeling Technics,Immunogold Silver Technics,Immunogold Silver Techniques,Immunogold Technic,Immunogold Technique,Immunogold-Silver Technic,Immunogold-Silver Technique,Immunolabeling Technic,Immunolabeling Technique,Technic, Immunogold,Technic, Immunogold-Silver,Technic, Immunolabeling,Technics, Immunogold,Technics, Immunogold-Silver,Technics, Immunolabeling,Technique, Immunogold,Technique, Immunogold-Silver,Technique, Immunolabeling,Techniques, Immunogold,Techniques, Immunogold-Silver,Techniques, Immunolabeling
D008297	Male		Males
D002452	Cell Count	The number of CELLS of a specific kind, usually measured per unit volume or area of sample.	Cell Density,Cell Number,Cell Counts,Cell Densities,Cell Numbers,Count, Cell,Counts, Cell,Densities, Cell,Density, Cell,Number, Cell,Numbers, Cell
D000367	Age Factors	Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.	Age Reporting,Age Factor,Factor, Age,Factors, Age
D000375	Aging	The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.	Senescence,Aging, Biological,Biological Aging
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D017208	Rats, Wistar	A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.	Wistar Rat,Rat, Wistar,Wistar Rats
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus
D018891	Dentate Gyrus	GRAY MATTER situated above the GYRUS HIPPOCAMPI. It is composed of three layers. The molecular layer is continuous with the HIPPOCAMPUS in the hippocampal fissure. The granular layer consists of closely arranged spherical or oval neurons, called GRANULE CELLS, whose AXONS pass through the polymorphic layer ending on the DENDRITES of PYRAMIDAL CELLS in the hippocampus.	Dentate Fascia,Fascia Dentata,Gyrus Dentatus,Area Dentata,CA4 Field of Hippocampal Formation,CA4 Region, Hippocampal,CA4 of Lorente de No,Cornu Ammonis 4 Area,Hilus Gyri Dentati,Hilus of Dentate Gyrus,Hilus of the Fascia Dentata,Hippocampal CA4 Field,Hippocampal Sector CA4,Area Dentatas,CA4 Field, Hippocampal,CA4, Hippocampal Sector,Dentata, Area,Dentata, Fascia,Dentatas, Area,Fascia, Dentate,Field, Hippocampal CA4,Gyrus, Dentate,Hippocampal CA4 Region,Region, Hippocampal CA4,Sector CA4, Hippocampal
D019006	Neural Cell Adhesion Molecules	Cell adhesion molecule involved in a diverse range of contact-mediated interactions among neurons, astrocytes, oligodendrocytes, and myotubes. It is widely but transiently expressed in many tissues early in embryogenesis. Four main isoforms exist, including CD56; (CD56 ANTIGEN); but there are many other variants resulting from alternative splicing and post-translational modifications. (From Pigott & Power, The Adhesion Molecule FactsBook, 1993, pp115-119)	Cell Adhesion Molecule, Neural,NCAM,Neural Cell Adhesion Molecule,Cell Adhesion Molecules, Neural