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The purpose of this study was to assess further the effect of amphetamine on negative symptoms of schizophrenia. Thirty-seven schizophrenic males meeting DSM-III criteria were rated with the Brief Psychiatric Rating Scale, the Abrams and Taylor Scale, and the Abnormal Involuntary Movements Scale before and after double-blind administration of either amphetamine (n = 26) or placebo (n = 11). Our results indicated that amphetamine administration generally did not improve negative symptoms, even when accounting for changes in positive symptoms. However, greater baseline negative symptoms were associated with a modest diminution after amphetamine treatment. Therefore, amphetamine may modestly improve negative symptoms in those schizophrenics in whom this symptomatology is more severe.
M Sanfilipo, and
A Wolkin, and
B Angrist, and
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E Duncan, and
S Wieland, and
T B Cooper, and
E D Peselow, and
J Rotrosen
April 1988,
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A Wolkin, and
B Angrist, and
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E Duncan, and
S Wieland, and
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E D Peselow, and
J Rotrosen
January 1980,
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M Sanfilipo, and
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E D Peselow, and
J Rotrosen
July 1984,
Indian journal of psychiatry,
M Sanfilipo, and
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B Angrist, and
D P van Kammen, and
E Duncan, and
S Wieland, and
T B Cooper, and
E D Peselow, and
J Rotrosen
May 1984,
The American journal of psychiatry,
M Sanfilipo, and
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March 1992,
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November 1991,
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June 1995,
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J Rotrosen
March 1987,
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June 1993,
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M Sanfilipo, and
A Wolkin, and
B Angrist, and
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E Duncan, and
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T B Cooper, and
E D Peselow, and
J Rotrosen
August 1990,
Canadian journal of psychiatry. Revue canadienne de psychiatrie,
