Biomaterial Database

[Molecular and biological features of human CD34+ Hematopoietic stem/progenitor cells]. 1995

Y Z Xi

Department of Hematopoiesis, Institute of Basic Medical Sciences, Beijing.

It is generally held that control of viability, proliferation, differentiation, maturation and programmed cell death events in hematopoietic stem/progenitor cells existing in a hierarchical fashion in vivo is a successively developmental process. The CD34+ antigen preferentialy expressed on hematopoietic stem/progenitor cells has so far been recognized as one of the earliest known antigens. Many advances on molecular structure of CD34 antigen would help us to understand deeply a lot of important questions regarding CD34+ hematopoietic stem/progenitor cells. These questions are, for instances, functional subclass, expression range and other biological properties including cell cycle state, fluorescent light scatter, ect. All of these studies would renew and consummate the modern concept of hematopoietic stem cells and the fundamental model of hematopoiesis and its regulation.

UI	MeSH Term	Description	Entries
D006412	Hematopoietic Stem Cells	Progenitor cells from which all blood cells derived. They are found primarily in the bone marrow and also in small numbers in the peripheral blood.	Colony-Forming Units, Hematopoietic,Progenitor Cells, Hematopoietic,Stem Cells, Hematopoietic,Hematopoietic Progenitor Cells,Cell, Hematopoietic Progenitor,Cell, Hematopoietic Stem,Cells, Hematopoietic Progenitor,Cells, Hematopoietic Stem,Colony Forming Units, Hematopoietic,Colony-Forming Unit, Hematopoietic,Hematopoietic Colony-Forming Unit,Hematopoietic Colony-Forming Units,Hematopoietic Progenitor Cell,Hematopoietic Stem Cell,Progenitor Cell, Hematopoietic,Stem Cell, Hematopoietic,Unit, Hematopoietic Colony-Forming,Units, Hematopoietic Colony-Forming
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013234	Stem Cells	Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.	Colony-Forming Units,Mother Cells,Progenitor Cells,Colony-Forming Unit,Cell, Mother,Cell, Progenitor,Cell, Stem,Cells, Mother,Cells, Progenitor,Cells, Stem,Colony Forming Unit,Colony Forming Units,Mother Cell,Progenitor Cell,Stem Cell
D018952	Antigens, CD34	Glycoproteins found on immature hematopoietic cells and endothelial cells. They are the only molecules to date whose expression within the blood system is restricted to a small number of progenitor cells in the bone marrow.	CD34 Antigens,CD34 Antigen,Antigen, CD34