Cardiovascular and respiratory changes following exposure to a synthetic toxin of Ptychodiscus brevis. 1995

J Koley, and S Sinha, and A K Basak, and M Das, and S N Dube, and P K Majumder, and A K Gupta, and S Dasgupta, and B Koley
Department of Physiology, University College of Science and Technology, Calcutta, India.

The present study demonstrated cardiorespiratory effects of a synthetic phosphorus-containing ichthyotoxic metabolite elaborated by the marine dinoflagellate Ptychodiscus brevis in anaesthetised cats. The metabolite at a dose of 0.25-1.5 mg/kg i.v., resulted in a dose-dependent fall in blood pressure and such vasodepressor effect was associated with bradycardia. There is initial respiratory apnoea followed by increased rate and depth of respiration (hyperapnoea) following the administration of the toxin. The hypotensive response was accompanied by a decrease in aortic baroreceptor activity. The ECG showed atrioventricular conduction block, arrhythmia and depression of S-T segment and T wave which indicated coronary insufficiency. Vasodepressive property of the toxin is presumably muscarinic in nature as atropine counteracted the vasodepression.

UI MeSH Term Description Entries
D008297 Male Males
D009498 Neurotoxins Toxic substances from microorganisms, plants or animals that interfere with the functions of the nervous system. Most venoms contain neurotoxic substances. Myotoxins are included in this concept. Alpha-Neurotoxin,Excitatory Neurotoxin,Excitotoxins,Myotoxin,Myotoxins,Neurotoxin,Alpha-Neurotoxins,Excitatory Neurotoxins,Excitotoxin,Alpha Neurotoxin,Alpha Neurotoxins,Neurotoxin, Excitatory,Neurotoxins, Excitatory
D011311 Pressoreceptors Receptors in the vascular system, particularly the aorta and carotid sinus, which are sensitive to stretch of the vessel walls. Baroreceptors,Receptors, Stretch, Arterial,Receptors, Stretch, Vascular,Stretch Receptors, Arterial,Stretch Receptors, Vascular,Arterial Stretch Receptor,Arterial Stretch Receptors,Baroreceptor,Pressoreceptor,Receptor, Arterial Stretch,Receptor, Vascular Stretch,Receptors, Arterial Stretch,Receptors, Vascular Stretch,Stretch Receptor, Arterial,Stretch Receptor, Vascular,Vascular Stretch Receptor,Vascular Stretch Receptors
D011433 Propranolol A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs. Dexpropranolol,AY-20694,Anaprilin,Anapriline,Avlocardyl,Betadren,Dociton,Inderal,Obsidan,Obzidan,Propanolol,Propranolol Hydrochloride,Rexigen,AY 20694,AY20694,Hydrochloride, Propranolol
D011950 Receptors, Cholinergic Cell surface proteins that bind acetylcholine with high affinity and trigger intracellular changes influencing the behavior of cells. Cholinergic receptors are divided into two major classes, muscarinic and nicotinic, based originally on their affinity for nicotine and muscarine. Each group is further subdivided based on pharmacology, location, mode of action, and/or molecular biology. ACh Receptor,Acetylcholine Receptor,Acetylcholine Receptors,Cholinergic Receptor,Cholinergic Receptors,Cholinoceptive Sites,Cholinoceptor,Cholinoceptors,Receptors, Acetylcholine,ACh Receptors,Receptors, ACh,Receptor, ACh,Receptor, Acetylcholine,Receptor, Cholinergic,Sites, Cholinoceptive
D012119 Respiration The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration ( Breathing
D001794 Blood Pressure PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS. Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D002415 Cats The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801) Felis catus,Felis domesticus,Domestic Cats,Felis domestica,Felis sylvestris catus,Cat,Cat, Domestic,Cats, Domestic,Domestic Cat
D004141 Dinoflagellida Flagellate EUKARYOTES, found mainly in the oceans. They are characterized by the presence of transverse and longitudinal flagella which propel the organisms in a rotating manner through the water. Dinoflagellida were formerly members of the class Phytomastigophorea under the old five kingdom paradigm. Amphidinium,Dinoflagellata,Dinophyceae,Dinophycidae,Dinophyta,Dinophytes,Gambierdiscus toxicus,Gonyaulax,Gymnodinium,Peridinium,Pyrrhophyta,Pyrrophyta,Dinoflagellates
D005260 Female Females

Related Publications

J Koley, and S Sinha, and A K Basak, and M Das, and S N Dube, and P K Majumder, and A K Gupta, and S Dasgupta, and B Koley
March 1997, Biomedical and environmental sciences : BES,
J Koley, and S Sinha, and A K Basak, and M Das, and S N Dube, and P K Majumder, and A K Gupta, and S Dasgupta, and B Koley
January 1986, Toxicon : official journal of the International Society on Toxinology,
J Koley, and S Sinha, and A K Basak, and M Das, and S N Dube, and P K Majumder, and A K Gupta, and S Dasgupta, and B Koley
June 1997, Indian journal of experimental biology,
J Koley, and S Sinha, and A K Basak, and M Das, and S N Dube, and P K Majumder, and A K Gupta, and S Dasgupta, and B Koley
July 1985, The Journal of allergy and clinical immunology,
J Koley, and S Sinha, and A K Basak, and M Das, and S N Dube, and P K Majumder, and A K Gupta, and S Dasgupta, and B Koley
January 1988, Toxicon : official journal of the International Society on Toxinology,
J Koley, and S Sinha, and A K Basak, and M Das, and S N Dube, and P K Majumder, and A K Gupta, and S Dasgupta, and B Koley
June 1987, The Journal of allergy and clinical immunology,
J Koley, and S Sinha, and A K Basak, and M Das, and S N Dube, and P K Majumder, and A K Gupta, and S Dasgupta, and B Koley
January 1981, Toxicon : official journal of the International Society on Toxinology,
J Koley, and S Sinha, and A K Basak, and M Das, and S N Dube, and P K Majumder, and A K Gupta, and S Dasgupta, and B Koley
March 1987, Molecular pharmacology,
J Koley, and S Sinha, and A K Basak, and M Das, and S N Dube, and P K Majumder, and A K Gupta, and S Dasgupta, and B Koley
November 1982, Journal of neurochemistry,
J Koley, and S Sinha, and A K Basak, and M Das, and S N Dube, and P K Majumder, and A K Gupta, and S Dasgupta, and B Koley
March 2002, Toxicology letters,
Copied contents to your clipboard!