In vivo regeneration of vestibular hair cells of guinea pig. 1995

H Yamane, and T Nakagawa, and H Iguchi, and S Shibata, and M Takayama, and K Nishimura, and Y Nakai
Department of Otolaryngology, Osaka City University Medical School, Japan.

Recent studies have shown that inner ear sensory cells may regenerate in mammals as well as in birds. In this in vivo study we investigated the regeneration of vestibular hair cells in guinea pigs after gentamycin intoxication, and found that the vestibular sensory epithelia reproduced new hair cells 30 days after degeneration, due to 30 consecutive days of gentamycin treatment. From the regeneration pattern of sensory epithelia, the supporting cells were identified as the progenitors of hair cells.

UI MeSH Term Description Entries
D009410 Nerve Degeneration Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways. Neuron Degeneration,Degeneration, Nerve,Degeneration, Neuron,Degenerations, Nerve,Degenerations, Neuron,Nerve Degenerations,Neuron Degenerations
D009416 Nerve Regeneration Renewal or physiological repair of damaged nerve tissue. Nerve Tissue Regeneration,Nervous Tissue Regeneration,Neural Tissue Regeneration,Nerve Tissue Regenerations,Nervous Tissue Regenerations,Neural Tissue Regenerations,Regeneration, Nerve,Regeneration, Nerve Tissue,Regeneration, Nervous Tissue,Regeneration, Neural Tissue,Tissue Regeneration, Nerve,Tissue Regeneration, Nervous,Tissue Regeneration, Neural
D005839 Gentamicins A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS. Gentamicin Sulfate (USP),Gentamycin,G-Myticin,Garamycin,Gentacycol,Gentamicin,Gentamicin Sulfate,Gentamycins,Gentavet,Genticin,G Myticin,GMyticin,Sulfate, Gentamicin
D006168 Guinea Pigs A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research. Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D018069 Hair Cells, Vestibular Sensory cells in the acoustic maculae with their apical STEREOCILIA embedded in a gelatinous OTOLITHIC MEMBRANE. These hair cells are stimulated by the movement of otolithic membrane, and impulses are transmitted via the VESTIBULAR NERVE to the BRAIN STEM. Hair cells in the saccule and those in the utricle sense linear acceleration in vertical and horizontal directions, respectively. Vestibular Hair Cells,Hair Cell, Vestibular,Vestibular Hair Cell

Related Publications

H Yamane, and T Nakagawa, and H Iguchi, and S Shibata, and M Takayama, and K Nishimura, and Y Nakai
July 1989, Hearing research,
H Yamane, and T Nakagawa, and H Iguchi, and S Shibata, and M Takayama, and K Nishimura, and Y Nakai
June 1991, Neuroscience letters,
H Yamane, and T Nakagawa, and H Iguchi, and S Shibata, and M Takayama, and K Nishimura, and Y Nakai
January 1993, Zhonghua er bi yan hou ke za zhi,
H Yamane, and T Nakagawa, and H Iguchi, and S Shibata, and M Takayama, and K Nishimura, and Y Nakai
January 1979, Advances in oto-rhino-laryngology,
H Yamane, and T Nakagawa, and H Iguchi, and S Shibata, and M Takayama, and K Nishimura, and Y Nakai
September 1993, The European journal of neuroscience,
H Yamane, and T Nakagawa, and H Iguchi, and S Shibata, and M Takayama, and K Nishimura, and Y Nakai
January 1990, Journal of vestibular research : equilibrium & orientation,
H Yamane, and T Nakagawa, and H Iguchi, and S Shibata, and M Takayama, and K Nishimura, and Y Nakai
July 2001, Chinese medical journal,
H Yamane, and T Nakagawa, and H Iguchi, and S Shibata, and M Takayama, and K Nishimura, and Y Nakai
November 1996, Nihon Jibiinkoka Gakkai kaiho,
H Yamane, and T Nakagawa, and H Iguchi, and S Shibata, and M Takayama, and K Nishimura, and Y Nakai
January 1991, ORL; journal for oto-rhino-laryngology and its related specialties,
H Yamane, and T Nakagawa, and H Iguchi, and S Shibata, and M Takayama, and K Nishimura, and Y Nakai
November 1995, Acta oto-laryngologica,
Copied contents to your clipboard!