Biomaterial Database

Urinary excretion of beta 2-microglobulin predicts renal outcome in patients with idiopathic membranous nephropathy. 1995

L J Reichert, and R A Koene, and J F Wetzels

Department of Medicine, University Hospital Nijmegen, Netherlands.

In patients with membranous nephropathy, treatment should be limited to those at risk for disease progression. Urinary beta 2-microglobulin excretion was measured in 30 patients with membranous nephropathy, a nephrotic syndrome, and normal renal function (endogenous creatinine clearance > 80 mL/min), who were subsequently monitored for a median of 48 months. Renal function deteriorated in 11 of the 14 patients with a beta 2-microglobulin excretion > 500 ng/min and in only 2 of the 16 patients with a beta 2-microglobulin excretion < or = 500 ng/min (P < 0.001). The measurement of urinary beta 2-microglobulin excretion thus contributes to the identification of patients with membranous nephropathy at high risk for developing renal insufficiency and may provide guidance for early immunosuppressive treatment.

UI	MeSH Term	Description	Entries
D007166	Immunosuppressive Agents	Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.	Immunosuppressant,Immunosuppressive Agent,Immunosuppressants,Agent, Immunosuppressive,Agents, Immunosuppressive
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D005260	Female		Females
D005500	Follow-Up Studies	Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.	Followup Studies,Follow Up Studies,Follow-Up Study,Followup Study,Studies, Follow-Up,Studies, Followup,Study, Follow-Up,Study, Followup
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D001613	beta 2-Microglobulin	An 11-kDa protein associated with the outer membrane of many cells including LYMPHOCYTES. It is the small subunit of MHC CLASS I MOLECULES. Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. Beta 2-microglobulin is present in small amounts in serum, CEREBROSPINAL FLUID, and urine of healthy individuals, and to a much greater degree in the urine and plasma of patients with tubular PROTEINURIA, renal failure, or kidney transplants.	Thymotaxin,beta 2 Microglobulin
D001706	Biopsy	Removal and pathologic examination of specimens from the living body.	Biopsies
D012189	Retrospective Studies	Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.	Retrospective Study,Studies, Retrospective,Study, Retrospective