-transparent.png){kind=logo}
The short- and long-term effects of the angiotensin-converting enzyme inhibitor lisinopril and the cardioselective beta-blocker bisoprolol on serum lipids, lipoproteins, apolipoproteins, and lipoprotein(a) (Lp[a]) levels were investigated in patients with mild-to-moderate essential hypertension. Fifty-two patients completed the 12-month, randomized, multicenter trial. After administration of lisinopril (10 to 20 mg/d; n = 24) and bisoprolol (2.5 to 10 mg/d; n = 28), systolic and diastolic blood pressures decreased significantly (P < 0.01) from baseline in both groups at 3, 6, and 12 months. The reduction in diastolic blood pressure was significantly (P < 0.05) greater in the lisinopril group than in the bisoprolol group only at 6 months. Heart rates dropped significantly in the bisoprolol group but not in the lisinopril group. No significant changes in lipids, lipoproteins, apolipoproteins, or Lp(a) levels were observed with either drug at 3, 6, or 12 months, and no significant differences were noted between the two drugs for these parameters. We conclude that lisinopril and bisoprolol are effective as antihypertensive drugs without adverse metabolic effects after short- and long-term treatment in patients with mild-to-moderate essential hypertension.
K Saku, and
K Liu, and
Y Takeda, and
S Jimi, and
K Arakawa
June 1992,
Journal of human hypertension,
K Saku, and
K Liu, and
Y Takeda, and
S Jimi, and
K Arakawa
November 2000,
Hypertension research : official journal of the Japanese Society of Hypertension,
K Saku, and
K Liu, and
Y Takeda, and
S Jimi, and
K Arakawa
July 2006,
Zhonghua xin xue guan bing za zhi,
K Saku, and
K Liu, and
Y Takeda, and
S Jimi, and
K Arakawa
January 1990,
Clinical therapeutics,
K Saku, and
K Liu, and
Y Takeda, and
S Jimi, and
K Arakawa
January 2007,
Advances in therapy,
K Saku, and
K Liu, and
Y Takeda, and
S Jimi, and
K Arakawa
January 1991,
The American journal of cardiology,
K Saku, and
K Liu, and
Y Takeda, and
S Jimi, and
K Arakawa
June 1991,
Journal of human hypertension,
K Saku, and
K Liu, and
Y Takeda, and
S Jimi, and
K Arakawa
February 1987,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
K Saku, and
K Liu, and
Y Takeda, and
S Jimi, and
K Arakawa
May 1999,
American journal of therapeutics,
K Saku, and
K Liu, and
Y Takeda, and
S Jimi, and
K Arakawa
December 1990,
Journal of clinical pharmacology,
