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BACKGROUND Alprazolam has proven efficacy as a treatment for panic disorder, but the place of other benzodiazepines is less well established. METHODS To compare the efficacy and tolerability of diazepam and alprazolam for the disorder, a placebo-controlled, double-blind trial was undertaken in two sites. Two hundred forty-one subjects with panic disorder or agoraphobia with panic attacks were randomly assigned to flexible doses of diazepam, alprazolam, or placebo for 8 weeks. RESULTS At the end of the trial, over 60% of subjects taking either diazepam or alprazolam were at least moderately improved compared with less than 30% of those taking placebo. On all measures of efficacy, subjects taking diazepam and alprazolam showed an equally favorable response. Despite some sedation early in the trial, both drugs were tolerated well. More severely ill subjects responded less well to either benzodiazepine. CONCLUSIONS The results indicate that diazepam is an effective alternative to alprazolam for the treatment of panic disorder.
R Noyes, and
G D Burrows, and
J H Reich, and
F K Judd, and
M J Garvey, and
T R Norman, and
B L Cook, and
P Marriott
July 1987,
The Journal of clinical psychiatry,
R Noyes, and
G D Burrows, and
J H Reich, and
F K Judd, and
M J Garvey, and
T R Norman, and
B L Cook, and
P Marriott
April 1991,
The Medical letter on drugs and therapeutics,
R Noyes, and
G D Burrows, and
J H Reich, and
F K Judd, and
M J Garvey, and
T R Norman, and
B L Cook, and
P Marriott
July 1991,
Biological psychiatry,
R Noyes, and
G D Burrows, and
J H Reich, and
F K Judd, and
M J Garvey, and
T R Norman, and
B L Cook, and
P Marriott
July 1989,
The American journal of psychiatry,
R Noyes, and
G D Burrows, and
J H Reich, and
F K Judd, and
M J Garvey, and
T R Norman, and
B L Cook, and
P Marriott
October 1984,
Texas medicine,
R Noyes, and
G D Burrows, and
J H Reich, and
F K Judd, and
M J Garvey, and
T R Norman, and
B L Cook, and
P Marriott
January 2002,
The Journal of the American Board of Family Practice,
R Noyes, and
G D Burrows, and
J H Reich, and
F K Judd, and
M J Garvey, and
T R Norman, and
B L Cook, and
P Marriott
May 1983,
The American journal of psychiatry,
R Noyes, and
G D Burrows, and
J H Reich, and
F K Judd, and
M J Garvey, and
T R Norman, and
B L Cook, and
P Marriott
June 1987,
Journal of clinical psychopharmacology,
R Noyes, and
G D Burrows, and
J H Reich, and
F K Judd, and
M J Garvey, and
T R Norman, and
B L Cook, and
P Marriott
September 1986,
The Journal of clinical psychiatry,
R Noyes, and
G D Burrows, and
J H Reich, and
F K Judd, and
M J Garvey, and
T R Norman, and
B L Cook, and
P Marriott
March 1990,
Pharmacopsychiatry,
