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Using reverse transcriptase-polymerase chain reaction we have established that mRNAs for prostaglandin H synthases 1 and 2 (PGHS-1 and PGHS-2) are present in amnion, chorion and decidua from women both at term before and after the onset of labour and from women at 28-35 weeks of gestation before the onset of labour. By Western blot analyses we have demonstrated that epidermal growth factor, interleukin 1 beta and phorbol 12-myristate 13-acetate all increase PGHS-2 amounts in amnion cells. The degree of stimulation caused by these substances (218-311 per cent) is less than the increase in prostaglandin production usually generated (five- to 10-fold). Hence we believe that these substances may have multiple sites of action in the pathways of arachidonic acid metabolism.
M S Trautman, and
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D Collmer, and
D J Dudley, and
D Simmons, and
M D Mitchell
January 1995,
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M S Trautman, and
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D J Dudley, and
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M D Mitchell
January 1996,
Acta physiologica Hungarica,
M S Trautman, and
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D Collmer, and
D J Dudley, and
D Simmons, and
M D Mitchell
January 1997,
Advances in experimental medicine and biology,
M S Trautman, and
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D Collmer, and
D J Dudley, and
D Simmons, and
M D Mitchell
March 1996,
Molecular and cellular endocrinology,
M S Trautman, and
S S Edwin, and
D Collmer, and
D J Dudley, and
D Simmons, and
M D Mitchell
July 1997,
The Journal of clinical endocrinology and metabolism,
M S Trautman, and
S S Edwin, and
D Collmer, and
D J Dudley, and
D Simmons, and
M D Mitchell
November 1999,
Prostaglandins, leukotrienes, and essential fatty acids,
M S Trautman, and
S S Edwin, and
D Collmer, and
D J Dudley, and
D Simmons, and
M D Mitchell
April 1995,
Endocrinology,
M S Trautman, and
S S Edwin, and
D Collmer, and
D J Dudley, and
D Simmons, and
M D Mitchell
January 2001,
Prostaglandins & other lipid mediators,
M S Trautman, and
S S Edwin, and
D Collmer, and
D J Dudley, and
D Simmons, and
M D Mitchell
January 2000,
Prostaglandins, leukotrienes, and essential fatty acids,
M S Trautman, and
S S Edwin, and
D Collmer, and
D J Dudley, and
D Simmons, and
M D Mitchell
January 1994,
Journal of reproduction and fertility,
