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To determine whether a large-dose antacid regimen is effective in promoting healing of duodenal ulcer, 74 patients with endoscopically proved duodenal ulcer completed a 28-day double-blind clinical trial comparing such a regimen with an inert placebo. The ulcer healed completely in 28 of the 36 antacid-treated as compared to 17 of the 38 placebo-treated patients (P less than 0.005). The antacid regimen was not more effective than placebo in relieving ulcer symptoms. Presence or absence of symptoms during the fourth treatment week was a poor predictor of presence or absence of an ulcer crater. Ulcers of placebo-treated patients who smoked cigarettes were less likely to heal than those of nonsmokers (P = 0.03). Except for mild diarrhea, no side effects of the antacid regimen were observed. We conclude that a large-dose antacid regimen hastens the healing of duodenal ulcer.
W L Peterson, and
R A Sturdevant, and
H D Frankl, and
C T Richardson, and
J I Isenberg, and
J D Elashoff, and
J Q Sones, and
R A Gross, and
R W McCallum, and
J S Fordtran
November 1985,
Scandinavian journal of gastroenterology,
W L Peterson, and
R A Sturdevant, and
H D Frankl, and
C T Richardson, and
J I Isenberg, and
J D Elashoff, and
J Q Sones, and
R A Gross, and
R W McCallum, and
J S Fordtran
January 1979,
Scandinavian journal of gastroenterology. Supplement,
W L Peterson, and
R A Sturdevant, and
H D Frankl, and
C T Richardson, and
J I Isenberg, and
J D Elashoff, and
J Q Sones, and
R A Gross, and
R W McCallum, and
J S Fordtran
October 1982,
Scandinavian journal of gastroenterology,
W L Peterson, and
R A Sturdevant, and
H D Frankl, and
C T Richardson, and
J I Isenberg, and
J D Elashoff, and
J Q Sones, and
R A Gross, and
R W McCallum, and
J S Fordtran
March 1978,
The New England journal of medicine,
W L Peterson, and
R A Sturdevant, and
H D Frankl, and
C T Richardson, and
J I Isenberg, and
J D Elashoff, and
J Q Sones, and
R A Gross, and
R W McCallum, and
J S Fordtran
December 1977,
The New England journal of medicine,
W L Peterson, and
R A Sturdevant, and
H D Frankl, and
C T Richardson, and
J I Isenberg, and
J D Elashoff, and
J Q Sones, and
R A Gross, and
R W McCallum, and
J S Fordtran
January 1987,
Acta medica Scandinavica,
W L Peterson, and
R A Sturdevant, and
H D Frankl, and
C T Richardson, and
J I Isenberg, and
J D Elashoff, and
J Q Sones, and
R A Gross, and
R W McCallum, and
J S Fordtran
February 1978,
The Practitioner,
W L Peterson, and
R A Sturdevant, and
H D Frankl, and
C T Richardson, and
J I Isenberg, and
J D Elashoff, and
J Q Sones, and
R A Gross, and
R W McCallum, and
J S Fordtran
January 1977,
Gastroenterologie clinique et biologique,
W L Peterson, and
R A Sturdevant, and
H D Frankl, and
C T Richardson, and
J I Isenberg, and
J D Elashoff, and
J Q Sones, and
R A Gross, and
R W McCallum, and
J S Fordtran
March 1988,
Gut,
W L Peterson, and
R A Sturdevant, and
H D Frankl, and
C T Richardson, and
J I Isenberg, and
J D Elashoff, and
J Q Sones, and
R A Gross, and
R W McCallum, and
J S Fordtran
October 1979,
Digestive diseases and sciences,
