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We report a case of pancreatic acinar cell carcinoma which contained a large number of pleomorphic inclusions with fibrillary internal structures and mature zymogen granules. To clarify the significance of fibrillary inclusions in the differentiation of acinar cells of the pancreas, we further investigated fetal pancreases (gestational weeks 16, 17, 19, 20 and 28). We found two types of inclusions: type A, corresponding to fibrillary inclusion of neoplastic acinar cells, was observed only in a 19-week fetus; type B showed a homogeneous density similar to that of zymogen granules. Type B was observed in all the fetuses after the 17th gestational week. Although the type A inclusion might be generated through a different mechanism than the type B inclusion, the appearance of a large number of fibrillary inclusions in neoplastic acinar cells may represent a transient form of zymogen granule.
J M Chong, and
M Fukayama, and
Y Shiozawa, and
Y Hayashi, and
N Funata, and
T Takizawa, and
M Koike
January 1990,
Histopathology,
J M Chong, and
M Fukayama, and
Y Shiozawa, and
Y Hayashi, and
N Funata, and
T Takizawa, and
M Koike
January 1994,
Ultrastructural pathology,
J M Chong, and
M Fukayama, and
Y Shiozawa, and
Y Hayashi, and
N Funata, and
T Takizawa, and
M Koike
January 1986,
Pancreas,
J M Chong, and
M Fukayama, and
Y Shiozawa, and
Y Hayashi, and
N Funata, and
T Takizawa, and
M Koike
October 1962,
Journal of ultrastructure research,
J M Chong, and
M Fukayama, and
Y Shiozawa, and
Y Hayashi, and
N Funata, and
T Takizawa, and
M Koike
September 2013,
The American journal of surgical pathology,
J M Chong, and
M Fukayama, and
Y Shiozawa, and
Y Hayashi, and
N Funata, and
T Takizawa, and
M Koike
January 1995,
Ultrastructural pathology,
J M Chong, and
M Fukayama, and
Y Shiozawa, and
Y Hayashi, and
N Funata, and
T Takizawa, and
M Koike
January 1984,
Journal of experimental pathology,
J M Chong, and
M Fukayama, and
Y Shiozawa, and
Y Hayashi, and
N Funata, and
T Takizawa, and
M Koike
November 1983,
Proceedings of the National Academy of Sciences of the United States of America,
J M Chong, and
M Fukayama, and
Y Shiozawa, and
Y Hayashi, and
N Funata, and
T Takizawa, and
M Koike
July 1980,
Cancer,
J M Chong, and
M Fukayama, and
Y Shiozawa, and
Y Hayashi, and
N Funata, and
T Takizawa, and
M Koike
May 1978,
Archives of pathology & laboratory medicine,
