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We reported that the major histocompatibility complex (MHC) including the null allele of the C4B gene and the extended haplotype B44-C30-DR4 is associated with autism. We report now that the third hypervariable region (HVR-3) of certain DR beta 1 alleles have very strong association with autism. The HVR-3 of DR beta 1* 0401 or the shared HVR-3 alleles DR beta 1* 0404 and DR beta 1* 0404 and DR *0101, was expressed on extended haplotypes in 23 of 50 (46%) autistic subjects as compared to only 6 of 79 (7.5%) normal subjects. Another HVR-3 sequence, the DR beta 1* 0701 allele, was carried on extended haplotypes in 16 (32.0%) of the autistic subjects as compared to 8 (10.1%) of the normal subjects.
R P Warren, and
J D Odell, and
W L Warren, and
R A Burger, and
A Maciulis, and
W W Daniels, and
A R Torres
November 1994,
Human immunology,
R P Warren, and
J D Odell, and
W L Warren, and
R A Burger, and
A Maciulis, and
W W Daniels, and
A R Torres
February 1992,
Arthritis and rheumatism,
R P Warren, and
J D Odell, and
W L Warren, and
R A Burger, and
A Maciulis, and
W W Daniels, and
A R Torres
October 2009,
Tissue antigens,
R P Warren, and
J D Odell, and
W L Warren, and
R A Burger, and
A Maciulis, and
W W Daniels, and
A R Torres
January 1996,
Acta microbiologica et immunologica Hungarica,
R P Warren, and
J D Odell, and
W L Warren, and
R A Burger, and
A Maciulis, and
W W Daniels, and
A R Torres
August 1982,
Tissue antigens,
R P Warren, and
J D Odell, and
W L Warren, and
R A Burger, and
A Maciulis, and
W W Daniels, and
A R Torres
May 1996,
Arthritis and rheumatism,
R P Warren, and
J D Odell, and
W L Warren, and
R A Burger, and
A Maciulis, and
W W Daniels, and
A R Torres
December 2000,
Human immunology,
R P Warren, and
J D Odell, and
W L Warren, and
R A Burger, and
A Maciulis, and
W W Daniels, and
A R Torres
December 1988,
Diabetes,
R P Warren, and
J D Odell, and
W L Warren, and
R A Burger, and
A Maciulis, and
W W Daniels, and
A R Torres
March 1996,
Proceedings of the National Academy of Sciences of the United States of America,
R P Warren, and
J D Odell, and
W L Warren, and
R A Burger, and
A Maciulis, and
W W Daniels, and
A R Torres
February 1980,
Proceedings of the National Academy of Sciences of the United States of America,
