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Cloning and sequence analysis of a hypothalamic cDNA encoding a D1c dopamine receptor in tilapia. 1996
A E Lamers, and
D Gröneveld, and
D P de Kleijn, and
F C Geeraedts, and
J A Leunissen, and
G Flik, and
S E Wendelaar Bonga, and
G J Martens
Department of Animal Physiology, Faculty of Science, University of Nijmegen, The Netherlands.
Physiological and pharmacological studies have indicated that during acid stress a D1-like dopamine receptor becomes functional on intermediate pituitary melanocyte-stimulating hormone cells of tilapia (Oreochromis mossambicus). As a first step towards physiological expression studies we isolated a D1-like dopamine receptor from a tilapia hypothalamus cDNA library. Construction of a phylogenetic tree of most of the D1-like receptors known in human, rat, Xenopus, goldfish and Drosophila revealed that the here presented clone is most likely the tilapia equivalent of the Xenopus D1c dopamine receptor.
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