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BACKGROUND Routine biochemical parameters in the blood of patients with chronic cardiopathies are nonspecific and of no reliable diagnostic value. OBJECTIVE Since marked changes of some biochemical blood parameters concerning the oxidative metabolism of the organism were observed in patients with acute myocardial diseases, the aim of this study was to estimate some antioxidant enzyme activities and metabolites in the blood of patients with cardiopathies-diseases with chronic heart failure of unknown origin. METHODS In 21 hospitalized patients with cardiopathy the venous blood samples were analyzed for plasma levels of thiobarbituric acid reactive substances (TBARS) as representatives of lipid peroxidation, levels of selenium and zinc as well as the activities of superoxide dismutase (SOD) and glutathione peroxidase (GPX) and reduced glutathione (GSH) level in erythrocytes. RESULTS Comparing the group of 25 clinically healthy individuals some marked changes in enzyme activities and metabolite levels were found in patients with cardiopathy: a significant increase of plasma TBARS and-on the other hand-markedly decreased activities of SOD and GPX and of GSH level in erythrocytes. Also a decreased plasma selenium level was observed in patients. CONCLUSIONS A marked decrease of antioxidant enzyme activities and GSH levels suggest a possible drop in total antioxidant status of patients with cardiopathy. Raised TBARS plasma levels might be regarded as a decreased ability of organism to abolish the produced free reactive oxygen forms leading thus to rise in lipoprotein rare.
I Pechán, and
H Minárová, and
F Babusíková, and
V Rendeková, and
S Mizera, and
E Schrameková, and
M Ursínyiová, and
J Fabián
January 2011,
Klinicheskaia meditsina,
I Pechán, and
H Minárová, and
F Babusíková, and
V Rendeková, and
S Mizera, and
E Schrameková, and
M Ursínyiová, and
J Fabián
August 2020,
Turkish journal of medical sciences,
I Pechán, and
H Minárová, and
F Babusíková, and
V Rendeková, and
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E Schrameková, and
M Ursínyiová, and
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January 2008,
Advances in therapy,
I Pechán, and
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November 2016,
Archives of dermatological research,
I Pechán, and
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January 2020,
Journal of biological regulators and homeostatic agents,
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January 2006,
Romanian journal of internal medicine = Revue roumaine de medecine interne,
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July 2007,
Polskie Archiwum Medycyny Wewnetrznej,
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August 2013,
Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale,
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December 2006,
Metabolic brain disease,
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January 2013,
La Clinica terapeutica,
