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[Synthesis of selected derivatives of 3H-pyrido[2,3-d]pyrimidin-4-on and potential depressive action on OUN]. 1992

F Herold
Zakład Technologii Srodków Leczniczych, Instytut Nauki o Leku, Akademia Medyczna, Warszawa.

2-Methyl-4H-pyrido[2,3-d][1,3]oxazin-4-one (III) was reacted with amines IVa-j to give corresponding 2-methyl-3H-pyrido[2,3-d]pyrimidin-4-ones (Va-j) substituted at position 3. These reactions afforded non-cyclic by-products VIa', VIg', and VIh' which were converted into compounds Va, Vg and Vh by the action of POCl3. Structures of the newly obtained compounds have been confirmed by elemental analysis for C, H and N, and by IR and 1H NMR spectra.

UI MeSH Term Description Entries
D011743 Pyrimidines A family of 6-membered heterocyclic compounds occurring in nature in a wide variety of forms. They include several nucleic acid constituents (CYTOSINE; THYMINE; and URACIL) and form the basic structure of the barbiturates.
D002492 Central Nervous System Depressants A very loosely defined group of drugs that tend to reduce the activity of the central nervous system. The major groups included here are ethyl alcohol, anesthetics, hypnotics and sedatives, narcotics, and tranquilizing agents (antipsychotics and antianxiety agents). CNS Depressants,Depressants, CNS
D000588 Amines A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed) Amine

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